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Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned

by Dr. Trupti Shirole on  January 27, 2011 at 1:20 PM Drug News   - G J E 4
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After several years of debate regarding the safety of nimesulide, cisapride and phenylpropanolamine (PPA) the Drug Controller General of India (DCGI) Dr. Surinder Singh has finally decided to ban these three unsafe drugs. Since the adverse effects of these drugs outweigh the benefits the Drugs Technical Advisory Board (DTAB) that had been examining the safety of the three drugs for several years has now recommended their withdrawal from the market.
 Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned
Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned

Nimesulide was the most controversial among the three drugs. Many developed countries like US, Britain, Canada, Sweden, Denmark, Australia, New Zealand, Japan and other 168 countries had already banned these drugs. However it is freely sold in India by prominent pharmaceutical companies like Dr Reddy's, Panacea Biotech and several others. Cisapride, another unsafe drug was found to increase upper gastrointestinal tract motility. Due to its side effects even this drug is banned in many countries. The drug continued to remain in the market even though the possible dangerous side effects of the drug had been brought to the notice of the DCGI 10years back. PPA used in cold and cough remedies is freely available in India. However it was banned in North America and Western Europe some years ago. The DTAB is now reviewing the use of Gatifloxacin, tegaserod and deanxit which have been banned in some of the developed countries. In the past diabetes drug Rosiglitazone and anti-obesity drug Rimonabant have been banned from the Indian markets.

This shows the need for stricter evaluation of safety and efficacy of any new drug before introducing it in the market.

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It is a tragedy that nimuselide has become a victim of marketing strategy and has been banned. This drug is safer and more effective then paracetamol. The judges and counselors involvement in the ban have been a weapon to bring about a ban to an effective drug that has been utilized for years with out much side effect. In certain context it has been safer then paracetamol. In the pediatric group it has been safer then paracetamol in many clinical conditions. The judges and lawyers involved have not done there job to bring about this ban, They definitely had the wrong inputs. It has been one of the best inventions to mankind in the last thirty years which have been guillotined by vested pharmaceutical companies. In fact the pharmaceutical companies that have brought about this ban should be criminally prosecuted.
pratik62 Monday, October 24, 2011
I'm using NISE[nimesulide from DRL] from 6years and I never had any side effect because of that. And it works awesome for acute pain. I don't know why people get carried away! Nothing in this world have 100% advantages and no disadvantages. In my personal opinion, nimesulide works better than paracetamol for acute pain
anilreddy0102 Tuesday, August 09, 2011
Idiots wasn't need to be banned nimesulide,ppa and sibutramine bcoz in india they didn't caused fatal cases,in real they were safe.ppa & sibutramine is known for it's beneficial use in anti-decongestant(only ppa),obesity,fatigue,energy,sexual arousal,sleepiness,drowsiness, as respiratory stimulants,in urinary incontinence,anhedonia and in priaprism.look it has alot benefits. NOW WE DON'T HAVE ANY MEDICINE FOR ABOVE PURPOSE UNFORTUNATELY. Indian govt.should unbanned these medicines.people pls fight for it.
JaipurIndia Tuesday, May 17, 2011
Sir, Despite ban Phenypropanoleamine [PPA] is still continued to be on sale. infact many of the companies have replaced the safer pseudoephedrine salt with PPA despite the reports of poor safety profile. Only strict action against these companies will help to safegaurd the patients, like cancellation of their licences and imposing heavy fines worth crores.
Malhotra Monday, February 28, 2011
Sir, So many drugs have already banned but it is not effected legally.Why? No chemist has been arrested till now.If any chemist has been arrested for saling ie,nimesulide,phenylpropanolamin etc.,it will be the legal record in India. Comment from A.Debendro Singh,Manipur.
Asem5 Thursday, February 24, 2011
when was this drug banned officially. Have the drug department sent notices of withdrawal from the market. How much time have been given.
PPPLCBE Tuesday, February 22, 2011
there are lots of several drugs which are yet to ban, which are already banned in developed nations and do not recommend by WHO. Thanks to our certain politicians and certain pharma companies. See this link http://www.youtube.com/watch?v=grKP2iQNQmc and feature=related
sunzeev Saturday, January 29, 2011
The drug nimesulide was used as substitute for very commonly used paracetamol for fever ,usually doctors used this drug in childerens and it is considered far safer than paracetamol ,likewise cisapride was used mostly in childerens for constipation and phenylpropanolamine [PPA]is used commonly for flue symptoms. If it was known for 10 years that these drugs are banned in several countries ,why we took so much time to ban them?. At last we have banned them,but what about the several side effects it has caused the innocent childerens and elders ,unknowingly and blindly trusting doctors our society has used these drugs .It is a fact that all drugs in allopathy have side effects ,if the adverse effects of drugs are more than its benefits then those drugs are banned. In my view we all must stop using allopathy medicines and shift towords ancient indian medicines in form of Ayurveda or Unani Or Homeopathy,Naturopathy etc. These medicines are produced through plants unlike Allopathy medicines which are made up from chemicals.Chemicals are bound to have side effects. SO we must use only natural medicines.
milindkumar Friday, January 28, 2011
With the drug control authority in developed countries being what they are, how come these drugs were approved in the first place? Most probably, these drugs were coming off their proprietary period, when they could be freely produced by anybody, hence the need for banning them.
raghu70 Thursday, January 27, 2011
Not after "several years of debate.." . After allowing time for the drug companies to recoup the investments. Do you think that inspite of many developed countries like US, Britain, Canada, Sweden, Denmark, Australia, New Zealand, Japan and other 168 countries had already banned these drugs, India needed a 'debate'?.
Mohmed Thursday, January 27, 2011

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