About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Zebrafish May Aid Research Into Motor Neuron Disease

by Dr. Enozia Vakil on May 24, 2013 at 9:16 PM
Font : A-A+

 Zebrafish May Aid Research Into Motor Neuron Disease

A new discovery made in fishes could aid the research into motor neuron disease.

Scientists have found that a key hormone allows young zebrafish to develop and replace their motor neurons - a kind of nerve cell found in the spinal cord.

Advertisement

The discovery may aid efforts to create neurons from stem cells in the lab, and support further research into a disorder for which there is still no cure.

In humans, motor neurons control important muscle activities such as speaking, walking and breathing. When these cells stop working, it causes difficulties in motor functions and leads to paralysis and death.
Advertisement

While humans cannot replace motor neurons when they break down, zebrafish can, making them a good model for research.

The study, led by scientists at the University of Edinburgh's Centre for Neuroregeneration, is the first to show that a signal released from the fish's brain - a hormone called dopamine - triggers the development and regeneration of cells in the spinal cord.

Dopamine acts on a mechanism - known as the hedgehog pathway - to increase the number of motor neurons formed in the developing spinal cord of zebrafish.

The dopamine signal was found to act in a similar way to replace damaged cells in adult zebrafish.

Dopamine was also found to drive the development of motor neurons in human embryonic stem cells, potentially paving the way for new and improved studies into motor neuron disease.

The work, published in the journal Developmental Cell, involved researchers from the Universities of Edinburgh, Cambridge, Helsinki and the Okazaki Institute for Integrative Biosciences, Japan.

It was mainly funded by the BBSRC, The Packard Center for ALS Research at Johns Hopkins, the Euan MacDonald Centre for MND Research at the University of Edinburgh and MND Scotland.

Dr Catherina Becker, Reader in Neurobiology at the University of Edinburgh's Centre for Neuroregeneration, and one of the lead authors of the study, said: "Our work sheds light on the way in which motor neurons develop and re-generate, and could inform research that leads to an increased understanding of motor neuron disease and spinal cord injuries."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS Parkinsons Disease AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs AIDS - Initial Theories and Disease Progression 

Recommended Reading
Advantage of Vitamin P as a Potential Approach for the Treatment of Damaged Motor Neurons
Biologists from the Ruhr-Universität Bochum have come up with findings after they explored how to .....
Treatment Targeted to Muscle Improves Motor Neuron Disease
New research with transgenic mice reveals that a therapy directed at the muscle significantly ......
Elusive Motor Neurons That Play a Vital Role in ALS Identified
A Northwestern Medicine researcher has managed to isolate the elusive motor neurons in the brain's ....
AIDS - Initial Theories and Disease Progression
AIDS was first detected in early 1980s, among gays, Haitians and black Africans. HIV is a descendant...
AIDS / HIV - Treatment
Encyclopedia section of medindia explains in brief about the treatment for AIDS/HIV...
AIDS/HIV
"AIDS is an epidemic disease, a potentially preventable, deadly infection for which there is no cure...
AIDS/HIV - Clinical Features
Encyclopedia section of medindia gives general info about HIV Clinical Features...
AIDS/HIV - Epidemiology
AIDS or HIV is an epidemic disease, a potentially deadly infection that can be prevented with preca...
AIDS/HIV - Health Education
Encyclopedia section of medindia gives general info about AIDS information and health education....
AIDS/HIV - Prevention And Transmission
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV...
Oral Health And AIDS
AIDS has taken on massive proportions in modern times. It is estimated that over 15 million people a...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use