About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Advantage of Vitamin P as a Potential Approach for the Treatment of Damaged Motor Neurons

by Thilaka Ravi on April 3, 2013 at 11:59 AM
Font : A-A+

Advantage of Vitamin P as a Potential Approach for the Treatment of Damaged Motor Neurons

Biologists from the Ruhr-Universitšt Bochum have reported findings after they explored how to protect neurons that control movements from dying off.

In the journal "Molecular and Cellular Neuroscience" they report that the molecule 7,8-Dihydroxyflavone, also known as vitamin P, ensures the survival of motor neurons in culture. It sends the survival signal on another path than the molecule Brain Derived Neurotrophic Factor (BDNF), which was previously considered a candidate for the treatment of motoneuron diseases or after spinal cord damage. "The Brain Derived Neurotrophic Factor only had a limited effect when tested on humans, and even had partially negative consequences", says Prof. Dr. Stefan Wiese from the RUB Work Group for Molecular Cell Biology. "Therefore we are looking for alternative ways to find new approaches for the treatment of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis."

Advertisement

Same effect, different mode of action

In previous studies, researchers hypothesised that vitamin P is an analogue of BDNF and thus works in the same way. This theory has been disproved by the team led by Dr. Teresa Tsai and Prof. Stefan Wiese from the Group for Molecular Cell Biology and the Department of Cell Morphology and Molecular Neurobiology headed by Prof. Andreas Faissner. Both substances ensure that isolated motor neurons of the mouse survive in cell culture and grow new processes, but what exactly the molecules trigger at the protein level varies. BDNF activates two signalling pathways, the so-called MAP kinase and PI3K/AKT signal paths. Vitamin P on the other hand makes use only of the latter.
Advertisement

The dose is crucial

However, vitamin P only unfolded its positive effects on the motor neurons in a very small concentration range. "These results show how important an accurate determination of dose and effect is", says Prof. Wiese. An overdose of vitamin P reduced the survival effect, and over a certain amount, no more positive effects occurred at all. The researchers hope that vitamin P could have less negative side effects than BDNF. "It is easier to use, because vitamin P, in contrast to BDNF, can pass the blood-brain barrier and therefore does not have to be introduced into the cerebrospinal fluid using pumps like BDNF," says Wiese.



Source: Eurekalert
Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Research News

Good Evening Recovery Leads to Better Work Days
A latest research suggests that the quality of a person's post-work recovery in the evening can impact their mood when they resume work the next day.
Link Between Sleep Apnea and Cognitive Decline
Researchers are working on new strategies and solutions for sleep apnea to ward off a range of health risks including cognitive decline.
Softening Stem Cells Enhances Hair Growth Potential
The scientists discovered that when the stem cells in the hair follicle are made softer, they have a higher chance of growing hair.
Potential New Strategy for Ischemic Stroke Discovered
A combinatorial therapy provided promising beneficial results among people with ischemic stroke.
Is Speech Therapy the Answer to Voice Problems in Parkinson's Disease Patients
In Parkinson's disease patients voice disorders are quite common. A new combination therapy had greater effects on the voice.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Advantage of Vitamin P as a Potential Approach for the Treatment of Damaged Motor Neurons Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests