About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Wound Healing Revolutionized With Mathematical Model Developed By Indian-Origin Scientist

by Tanya Thomas on September 24, 2009 at 8:33 AM
 Wound Healing Revolutionized With Mathematical Model Developed By Indian-Origin Scientist

A mathematical model of chronic wound healing, developed by researchers at the Ohio State University and led by an Indian-origin scientist, could possibly eliminate all guesswork and clearly suggest treatment strategies towards tackling this major public-health problem.

The researchers are the first to publish a mathematical model of an ischemic wound - a chronic wound that heals slowly or is in danger of never healing because it is fed by an inadequate blood supply.

Advertisement

Ischemic wounds are a common complication of diabetes, high blood pressure, obesity and other conditions that can be characterized by poor vascular health.

The wound model reduces the need for guesswork and time-consuming animal testing traditionally required as researchers pursue prevention, diagnosis and treatment of complex diseases.
Advertisement

"Before you treat any problem successfully, you have to understand it. Now that we have this model, we can take the next step to find what factors in the equations can be fine-tuned to the point where the net result is improvement in the ischemic wound outcome," said Chandan Sen.

The mathematical model, to date, simulates both non-ischemic wounds - those typical of wounds in healthy people with good circulation - and ischemic wounds.

The current model produced results that generally match pre-clinical expectations- that a normal wound will close in about 13 days, and that 20 days after the development of an ischemic wound, only 25 percent of the wound will be healed.

The model also showed that normal wounds have higher concentrations of proteins and cells expected to be present during the healing process, while ischemic wounds lack oxygen and remain in a prolonged inflammatory phase that interferes with the subsequent cascade of events required to begin wound closure.

In a recent study, Sen designed a biological pre-clinical model of an ischemic wound using the skin on a pig's back.

The new mathematical model- a system of partial differential equations-borrowed some data from the animal model, but also includes numerous calculations assigning values to the various cells and chemicals involved in the wound-healing process.

The study has been published in the online early edition of the Proceedings of the National Academy of Sciences.

Source: ANI
TAN
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Research News

Unlocking the Gut Microbiome's Influence on Bone Density
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
Hop-Derived Compound Reduces Gut Microbe Linked to Metabolic Syndrome
Consuming a diet rich in saturated fats triggers persistent, low-level inflammation within the body, ultimately contributing to the onset of metabolic syndrome.
Breakthrough in Mosquitoes for Fighting Dengue Fever
Ae. aegypti mosquitoes are carriers of "arthropod-borne" or "arbo-" viruses, which encompass the dengue virus, yellow fever virus, Zika virus, and chikungunya virus.
Cerebrospinal Fluid Leaks: Link to Traumatic Brain Injury and Dementia?
Cerebrospinal fluid (CSF) leaks are detected in approximately 1-3% of adults who have experienced a traumatic brain injury.
Astrocyte Activation Through Optogenetics: A New Hope in the Fight Against Alzheimer's
The optogenetic activation of hippocampal astrocytes can be viewed as a novel therapeutic avenue for addressing Alzheimer's disease.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Wound Healing Revolutionized With Mathematical Model Developed By Indian-Origin Scientist Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests