About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Will Micro-Nutrient Deficiency Risk Your Chances Of Getting Pregnant?

by Rishika Gupta on April 25, 2018 at 4:56 PM
Font : A-A+

 Will Micro-Nutrient Deficiency Risk Your Chances Of Getting Pregnant?

Zinc deficiency could be the reason behind ovulation disorders, which make pregnancy difficult for some couples, finds a new study. This micronutrient deficiency was found to affect egg development negatively. The findings of this study are going to be presented at the American Physiological Society annual meeting at Experimental Biology.

An estimated 10 percent of couples in the U.S. struggle with infertility. Ovulation disorders are one of the leading cause of female infertility. Researchers found that zinc deficiency was affecting the early stages of egg development negatively, and thereby reducing the ability of the egg cells to divide and be fertilized.

Advertisement


The availability of micronutrients in the ovarian environment and their influence on the development, viability, and quality of egg cells (oocytes) is the focus of a growing area of research. In mammals, the ovary is made up of thousands of structures called follicles--women are born with approximately two million--which consist of one oocyte surrounded by layers of support cells (somatic cells).

After puberty, a complex cascade of events occurs to prepare groups of oocytes for maturation, ovulation, and fertilization. Though a group of oocytes begins to mature each month, only one will be ovulated and have the chance of being fertilized. Multiple factors can influence whether a given oocyte will mature correctly and one day be ovulated, including the presence of sufficient levels of certain micronutrients.
Advertisement

"More and more evidence is accumulating that zinc is a key player in oocyte development," lead author James Hester said. In the current study, Hester and his adviser, Francisco Diaz, assessed the effects of zinc on egg development extremely early on in the oocyte maturation process.

"Fertility research and treatment has primarily focused on the largest class of follicles (antral follicles), which are capable of ovulating in response to hormonal signals from the pituitary gland," Hester wrote. "In contrast, our study examines smaller preantral follicles, which are still growing and don't respond to the ovulatory signal yet. In humans, preantral follicles have to keep growing for about 90 days before they are ready to ovulate. Previous studies showed that zinc levels are critical in the antral follicle, but no one had tested the effect of zinc deficiency on preantral follicle growth."

The researchers collected preantral follicles from mice and matured them in a cell culture dish. They compared eggs matured in a zinc-deficient environment to those grown with normal levels of zinc. They also exposed the zinc-deficient and control eggs to epidermal growth factor to mimic the hormonal environment necessary for ovulation after the maturation process.

Hester and Diaz found that preantral zinc deficiency:
  • Disrupted growth of cells in culture
  • Led to smaller egg cells early in development
  • Caused problems with the development of somatic cells and elevated certain cell markers
  • Impaired the egg cell's ability to properly divide (meiosis), a necessary step before successful fertilization can occur. This defect persisted even after more zinc was introduced to the environment
. "Animal studies have consistently shown a zinc requirement for oocytes during meiotic division, fertilization and embryo development. Our new research shows that zinc plays a role in oocyte growth at an earlier stage than previously investigated, during development and before division. Otherwise, it doesn't matter what the conditions are during ovulation," Hester explained. "Interestingly, the oocytes commonly used for [in vitro fertilization] are collected from antral follicles, so any effects from preantral development have already occurred."

While the World Health Organization estimates that 17 percent of the global population is vulnerable to zinc deficiency in their diet, the estimate may not include cases of marginal zinc deficiency (people with some zinc in their diet, but less than recommended).

Other at-risk populations include people with dietary and disease factors that also affect zinc statuses such as irritable bowel syndrome, Crohn's disease, gastrointestinal disorders and liver disease; women facing food insecurity; or women with certain dietary restrictions, such as vegetarians or vegans who don't take supplemental zinc.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
New Test Can Predict Risks of Developing Premature Ovarian Aging Early in Women
A test called "what's my fertility" will help women to know how fertile they are and about the ......
Can Ovarian Reserve Predict Fertility in Older Women?
The chances of conception in older women cannot be predicted with tests that estimate ovarian ......
Most Fertility Tracker Apps are Unreliable and Miscalculate the Fertile Window
If you rely on a fertility app to track your cycle, bad news. Most of them miscalculate the fertile ...
Social Acceptance Takes Priority In Fertility Treatment
For the first time new research has assessed the relative importance of the role that economic, ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use