The most common cause of dementia among older people, Alzheimer's disease, currently has no effective drugs to stop, slow or prevent disease progression. A study online December 5th in the ISSCR's journal Stem Cell Reports, published by Cell Press, provide interesting clues on why non-steroidal anti-inflammatory drugs (NSAIDs), which have successfully treated molecular signs of Alzheimer's disease in cell and animal models, eventually failed in clinical studies. Whereas the compounds worked in non-neuronal cells lines typically used in pharmaceutical drug screening, the authors found that human neurons are resistant to this class of drugs. "The results of our study are significant for future drug development approaches, because they imply that compound screening and validation studies might be much more reliable if they are conducted using the human cell type affected by the disease in question," says Oliver Brüstle of the University of Bonn who senior-authored the study together with his colleague Philipp Koch. Source: Eurekalert << Johns Hopkins Research Finds Membrane Enzymes 'Stop and Fri... Risk for Serious Sleep Breathing Disorder is High in Quadri... >> Recommended Reading Alzheimers Disease Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others. READ MORE Brain Exercises to Improve Memory An active brain can certainly help in improving memory by strengthening the connections between neural impulses in brain. READ MORE Undetected Nutrient Deficiencies: The Cause of Ill Health Micronutrient and antioxidant deficiencies are most common and go unnoticed. They are the root cause of most lifestyle related diseases. READ MORE Vitamin B12 - An Essential Vitamin If you feel that the persistent or regular incidences of depression have got nothing to do with what you eat, think again. The reason behind low spirits can be due to insufficient levels vitamin B12. READ MORE Clinical Trials Clinical trials are experiments that yield useful information to clinicians if a particular treatment is of any value to a patient. READ MORE Clinical Trials - Different Phases of the trial Clinical trials serve as a vital component for improving the treatment of medical conditions as they lead to higher standards of patient care. READ MORE Clinical Trials - The Past and The Future Many of the drugs that are used today have been discovered by chance or often by mere serendipity READ MORE Dementia Dementia has become a very big concern as we have an aging population across the world. Dementia is also terrifying to us because of its disturbing symptoms and limited treatment options. READ MORE Drug Toxicity Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. READ MORE Drugs Banned in India Several drugs are either banned or withdrawn after introduction in the market. READ MORE Placebo Effects: Rare Insights Placebo response is now generally well accepted. ‘Placebo response’ is the friend of the clinician and enemy of disease’. READ MORE Vascular Dementia Vascular dementia is the second most common form of dementia. Though it has no cure, you can still learn to manage its symptoms and lead a joyful life. READ MORE Most Popular on Medindia Daily Calorie Requirements Diaphragmatic Hernia Hearing Loss Calculator More News on: Alzheimers DiseaseDrug ToxicityClinical TrialsClinical Trials - The Past and The FutureClinical Trials - Different Phases of the trialDrugs Banned in IndiaPlacebo Effects: Rare InsightsDementiaVascular Dementia
The most common cause of dementia among older people, Alzheimer's disease, currently has no effective drugs to stop, slow or prevent disease progression. A study online December 5th in the ISSCR's journal Stem Cell Reports, published by Cell Press, provide interesting clues on why non-steroidal anti-inflammatory drugs (NSAIDs), which have successfully treated molecular signs of Alzheimer's disease in cell and animal models, eventually failed in clinical studies. Whereas the compounds worked in non-neuronal cells lines typically used in pharmaceutical drug screening, the authors found that human neurons are resistant to this class of drugs. "The results of our study are significant for future drug development approaches, because they imply that compound screening and validation studies might be much more reliable if they are conducted using the human cell type affected by the disease in question," says Oliver Brüstle of the University of Bonn who senior-authored the study together with his colleague Philipp Koch. Source: Eurekalert << Johns Hopkins Research Finds Membrane Enzymes 'Stop and Fri... Risk for Serious Sleep Breathing Disorder is High in Quadri... >> Recommended Reading Alzheimers Disease Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others. READ MORE Brain Exercises to Improve Memory An active brain can certainly help in improving memory by strengthening the connections between neural impulses in brain. READ MORE Undetected Nutrient Deficiencies: The Cause of Ill Health Micronutrient and antioxidant deficiencies are most common and go unnoticed. They are the root cause of most lifestyle related diseases. READ MORE Vitamin B12 - An Essential Vitamin If you feel that the persistent or regular incidences of depression have got nothing to do with what you eat, think again. The reason behind low spirits can be due to insufficient levels vitamin B12. READ MORE Clinical Trials Clinical trials are experiments that yield useful information to clinicians if a particular treatment is of any value to a patient. READ MORE Clinical Trials - Different Phases of the trial Clinical trials serve as a vital component for improving the treatment of medical conditions as they lead to higher standards of patient care. READ MORE Clinical Trials - The Past and The Future Many of the drugs that are used today have been discovered by chance or often by mere serendipity READ MORE Dementia Dementia has become a very big concern as we have an aging population across the world. Dementia is also terrifying to us because of its disturbing symptoms and limited treatment options. READ MORE Drug Toxicity Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. READ MORE Drugs Banned in India Several drugs are either banned or withdrawn after introduction in the market. READ MORE Placebo Effects: Rare Insights Placebo response is now generally well accepted. ‘Placebo response’ is the friend of the clinician and enemy of disease’. READ MORE Vascular Dementia Vascular dementia is the second most common form of dementia. Though it has no cure, you can still learn to manage its symptoms and lead a joyful life. READ MORE Most Popular on Medindia Daily Calorie Requirements Diaphragmatic Hernia Hearing Loss Calculator More News on: Alzheimers DiseaseDrug ToxicityClinical TrialsClinical Trials - The Past and The FutureClinical Trials - Different Phases of the trialDrugs Banned in IndiaPlacebo Effects: Rare InsightsDementiaVascular Dementia
