Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the hippocampus and neocortex. However, the relationship between Cajal-Retzius cells and Alzheimer's disease is still unknown.

The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer's disease amyloid pathology and related behavioral defcits. Overall, these data, published in the Neural Regeneration Research (Vol. 9, No. 4, 2014), indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease.
Source-Eurekalert