Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the hippocampus and neocortex. However, the relationship between Cajal-Retzius cells and Alzheimer's disease is still unknown.
Dr. Jinbo Deng and team from Henan University in China revealed that the number of Cajal-Retzius cells markedly reduced with age in both wild type and in mice over-expressing the Swedish double mutant form of amyloid precursor protein 695 (transgenic (Tg) 2576 mice).
Alzheimers Disease
Alzheimer''s disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.
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The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer's disease amyloid pathology and related behavioral defcits. Overall, these data, published in the Neural Regeneration Research (Vol. 9, No. 4, 2014), indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer's disease.
Source: Eurekalert
Risk Factors for Alzheimers Disease
Cognitively normal adults exhibiting atrophy of their temporal lobe or damage to blood vessels in the brain are more likely to develop Alzheimer's disease.
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 Young Blood to Cure Decline of Aging BrainA research showed that injections of juvenile mouse blood boosts learning and memory in older rodents, findings that hold the long-sought cure for the decline of ageing brain. | Advertisement
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Risk Factors for Alzheimer's Disease Depend on Gender
French researchers have found that the risk factors for developing Alzheimer's disease are dependent on the gender of a person.
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