About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Triple-Therapy Treatment May Help Fight Resistant Lung Cancers

by Dr. Trupti Shirole on January 2, 2016 at 4:05 PM
Font : A-A+

 Triple-Therapy Treatment May Help Fight Resistant Lung Cancers

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Although NSCLC has recently seen major treatment advances in some genetic subtypes, other subtypes continue to evade effective treatment. Now, a new study in mice has shown that cancers with KRAS-related gene mutations might benefit from a triple therapy with two experimental drugs plus radiation therapy. The results were published in the Clinical Cancer Research.

Dr. Bo Lu, Professor of Radiation Oncology at Thomas Jefferson University, said, "Currently there is a clinical trial underway to evaluate the combination of two cancer drugs, trametinib and palbociclib, made by two pharma companies for patients with solid tumors and melanoma. Although further research in human subjects is needed to confirm the finding, our study suggests that we may be able to identify non-small cell lung cancer patients who are likely to benefit most from this combination of therapies."

Advertisement


Roughly 85% of all lung cancers belong to the NSCLC type. Although there have been some advances in treating this disease, only 2% of survivors live five years beyond treatment. Drugs have been developed to target the ALK- and EGFR-mutated subtypes, and are to some degree effective, however, one genetic subset, NSCLCs with mutations in the gene KRAS have been resistant to conventional and targeted therapies.

Here Dr. Lu and colleagues investigated the KRAS-mutant subset in NSCLC cells and found that there was variation within this subset; some were more resistant to a drug that targeted the KRAS gene pathway than others. An additional mutation in a protein called p16 appeared to be responsible for this difference. After scanning a database of lung-cancer patient genotypes, the researchers saw that patients with the p16 mutation had a lower overall survival rate than those without the mutation.
Advertisement

In order to help make these resistant KRAS mutants more susceptible to therapy, the researchers combined the KRAS-targeting drug with another drug that would undo the effects of the p16 mutation. Together, Dr. Lu's group showed, the combination of the two drugs make these resistant cancer cells susceptible to radiation treatment. "If you hit one target another can take over. If you hit two, it becomes a lethal bullet," said Dr. Lu.

Currently, neither of two drugs that target KRAS and proteins in the p16 pathway are approved for use in lung cancer. However, Dr. Lu hopes that this research will help identify the patients who could potentially benefit from a triple-therapy treatment.

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Lung Cancer Pneumoconiosis Silicosis 

Most Popular on Medindia

Accident and Trauma Care Drug - Food Interactions Calculate Ideal Weight for Infants How to Reduce School Bag Weight - Simple Tips Color Blindness Calculator Drug Side Effects Calculator Noscaphene (Noscapine) Indian Medical Journals Selfie Addiction Calculator Iron Intake Calculator
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Triple-Therapy Treatment May Help Fight Resistant Lung Cancers Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests