About Careers MedBlog Contact us

Transplantation of Fecal Matter can Treat Severe Infection in Patients

by Bidita Debnath on March 30, 2015 at 10:47 PM
Font : A-A+

Transplantation of Fecal Matter can Treat Severe Infection in Patients

Researchers have found that the transplantation of fecal matter successfully treated Clostridium difficile infections in patients, which lead to recurrent cases of diarrhea and severe abdominal pain with thousands of fatalities worldwide every year.

The results, published in Microbiome, revealed that healthy changes to the patients' microbiome were sustained for up to 21 weeks after transplant, and has implications for the regulation of the treatment.


"Our study shows that there are both short and long-term changes in the fecal microbiome following transplantation," said Michael Sadowsky from University of Minnesota.

For the research, Sadowsky and colleagues collected fecal samples from four patients before and after their fecal transplants. Three patients received freshly prepared microbiota from fecal matter and one patient received fecal microbiota that had previously been frozen.

All received fecal microbiota from the same pre-qualified donor. The team compared the pre- and post-transplant fecal microbial communities from the four patients, as well as from 10 additional patients with recurring C. difficile infections.

In addition, they looked at the changes in fecal bacterial composition in recipients over time, and compared this to the changes observed within samples from the donor.

Surprisingly, after transplantation, patient samples appeared to sustain changes in their microbiome for up to 21 weeks and remained within the spectrum of fecal microbiota characterised as healthy.

Clostridium difficile infections thought to work by overrunning the intestinal microbiome -- the ecosystem of microorganisms that maintain a healthy intestine.

Fecal microbiota transplantation was developed as a method of treating C. difficile infection and is particularly successful in patients who suffer repeat infections.

Fecal matter is collected from a donor, purified, mixed with a saline solution and placed in a patient, usually by colonoscopy. Previous research has shown that the fecal microbiota of patients resembles that of the donor, but not much was known till the new research about the short and long term stability of fecal microbiota transplanted into recipients.

Source: IANS


Recommended Reading

Latest Research News

Potential New Strategy for Ischemic Stroke Discovered
A combinatorial therapy provided promising beneficial results among people with ischemic stroke.
Is Speech Therapy the Answer to Voice Problems in Parkinson's Disease Patients
In Parkinson's disease patients voice disorders are quite common. A new combination therapy had greater effects on the voice.
 New Insights into How the Immune System Responds to Spinal-Cord Injuries
New study findings delineate how aging affects the immune response following Spinal cord injury (SCI) and highlight the participation of the spinal cord meninges in repair.
Nearsightedness: Atropine Eye Drops may Slow Progression in Kids
A recent clinical trial suggests that the first medication therapy to reduce the progression of nearsightedness in children could be on the way.
Autoimmune Diseases Affect One in Ten: Study
Autoimmune disorders were found to be linked to Sjogren's, systemic lupus erythematosus, and systemic sclerosis.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Transplantation of Fecal Matter can Treat Severe Infection in Patients Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests