Researchers have found that the transplantation of fecal matter successfully treated Clostridium difficile infections in patients, which lead to recurrent cases of diarrhea and severe abdominal pain with thousands of fatalities worldwide every year.
The results, published in Microbiome, revealed that healthy changes to the patients' microbiome were sustained for up to 21 weeks after transplant, and has implications for the regulation of the treatment.
Liver Transplantation from a Live Donor is Safe
Nearly 80-90% of the liver cells are severely damaged after the first signs of liver cells. A live or deceased donor transplant improves liver functions.
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"Our study shows that there are both short and long-term changes in the fecal microbiome following transplantation," said Michael Sadowsky from University of Minnesota.
For the research, Sadowsky and colleagues collected fecal samples from four patients before and after their fecal transplants. Three patients received freshly prepared microbiota from fecal matter and one patient received fecal microbiota that had previously been frozen.
![Corneal Tissue Transplantation Exhibits Success Rate]( "Corneal Tissue Transplantation Exhibits Success Rate")
Transplantation of corneal tissues is the new eye surgery technique with positive result seen among old age people.
All received fecal microbiota from the same pre-qualified donor. The team compared the pre- and post-transplant fecal microbial communities from the four patients, as well as from 10 additional patients with recurring C. difficile infections.
In addition, they looked at the changes in fecal bacterial composition in recipients over time, and compared this to the changes observed within samples from the donor.
Surprisingly, after transplantation, patient samples appeared to sustain changes in their microbiome for up to 21 weeks and remained within the spectrum of fecal microbiota characterised as healthy.
Clostridium difficile infections thought to work by overrunning the intestinal microbiome -- the ecosystem of microorganisms that maintain a healthy intestine.
Fecal microbiota transplantation was developed as a method of treating C. difficile infection and is particularly successful in patients who suffer repeat infections.
Fecal matter is collected from a donor, purified, mixed with a saline solution and placed in a patient, usually by colonoscopy. Previous research has shown that the fecal microbiota of patients resembles that of the donor, but not much was known till the new research about the short and long term stability of fecal microbiota transplanted into recipients.
Source: IANS
Corneal Tissue Transplantation Exhibits Success Rate
Transplantation of corneal tissues is the new eye surgery technique with positive result seen among old age people.
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All received fecal microbiota from the same pre-qualified donor. The team compared the pre- and post-transplant fecal microbial communities from the four patients, as well as from 10 additional patients with recurring C. difficile infections.
In addition, they looked at the changes in fecal bacterial composition in recipients over time, and compared this to the changes observed within samples from the donor.
Surprisingly, after transplantation, patient samples appeared to sustain changes in their microbiome for up to 21 weeks and remained within the spectrum of fecal microbiota characterised as healthy.
Clostridium difficile infections thought to work by overrunning the intestinal microbiome -- the ecosystem of microorganisms that maintain a healthy intestine.
Fecal microbiota transplantation was developed as a method of treating C. difficile infection and is particularly successful in patients who suffer repeat infections.
Fecal matter is collected from a donor, purified, mixed with a saline solution and placed in a patient, usually by colonoscopy. Previous research has shown that the fecal microbiota of patients resembles that of the donor, but not much was known till the new research about the short and long term stability of fecal microbiota transplanted into recipients.
Source: IANS
Pancreatic Islet Cell Transplantation Restores Type 1 Diabetics' Blood Sugar Defense Mechanisms
Type 1 diabetes (T1D) patients who have developed low blood sugar (hypoglycemia) as a complication of insulin treatments are able to regain normal internal recognition of the condition after receiving pancreatic islet cell transplantation.
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 Organs During Transplantation Protected by Drugs Preventing Blood ClotDuring transplantation, organs can become significantly damaged. A protective strategy to keep them safe and allow them to function optimally after the procedure has been offered. | Advertisement
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