About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Pancreatic Islet Cell Transplantation Restores Type 1 Diabetics' Blood Sugar Defense Mechanisms

by Bidita Debnath on December 20, 2014 at 11:38 PM
Font : A-A+

 Pancreatic Islet Cell Transplantation Restores Type 1 Diabetics' Blood Sugar Defense Mechanisms

Type 1 diabetes (T1D) patients who have developed low blood sugar (hypoglycemia) as a complication of insulin treatments are able to regain normal internal recognition of the condition after receiving pancreatic islet cell transplantation.

This is according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania, published online in Diabetes. Severe hypoglycemia--a life-threatening complication of insulin treatment for T1D--can occur when the body's defense mechanisms against low blood sugar are broken down over a long period of time, causing shakiness, irritability, confusion, lightheadedness, shortness of breath, and even seizures or loss of consciousness.

Advertisement

In this study, led by Michael R. Rickels, MD, MS, associate professor of Medicine and medical director of the Pancreatic Islet Cell Transplant Program at Penn Medicine, T1D patients who were suffering from "hypoglycemia unawareness"--when a patient has low blood sugar, but feels no symptoms--were able to internally recognize the condition and automatically increase their own blood sugar to normal levels six months after undergoing islet cell transplantation. Pancreatic islets are tiny clusters of cells within the pancreas that contain several types of cells, including cells that produce insulin to help the body process sugar.

"The results of this study suggest that islet cell transplantation may be an effective treatment for patients with type 1 diabetes who are experiencing significant hypoglycemic events because their body isn't able to recognize their low blood sugar levels," said Rickels. "Currently, islet cell transplantation is considered investigational for type 1 diabetes patients, but this study shows that it has the potential to dramatically improve a patient's ability to defend against and recognize symptoms of hypoglycemia and eliminate severe hypoglycemic episodes."
Advertisement

Patients who undergo pancreatic islet cell transplantation receive islets from deceased donors, sometimes through two separate infusions. In this study, 12 patients with hypoglycemia unawareness and frequent severe hypoglycemia events underwent either one or two infusions of islets in order to achieve insulin-independence. The subjects all had approximately 30 years of disease history before the infusion, and their bodies' ability to recognize hypoglycemia was measured prior to the infusion and at six to seven months afterwards. The results were then compared to a control group. Following the islet cell transplantation, the subjects' time spent hypoglycemic was nearly abolished. In addition, their bodies were able to appropriately respond to experimental insulin-induced hypoglycemia following transplantation.

"Now that we've seen improvement in the protection against hypoglycemia as a result of islet cell transplantation, we're evaluating the longer term durability of these restored defense mechanisms," said Rickels. Additional work in the laboratory of Ali Naji, MD, PhD, the J. William White professor of Surgery and co-director of the Type 1 Diabetes Unit for Penn's Institute for Diabetes, Obesity and Metabolism, is aimed at the development of new immunosuppression medication approaches to reduce the risk for adverse side effects.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ten Fruits for Diabetics
Natural Supplements Help Reverse Hair Loss during Menopause
Ways to Manage Stress during COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Pancreatic Cancer Thalassemia Otitis Media Diabetes - Essentials Parkinsons Disease Surgical Treatment Diabetes - Self-Monitoring of Blood Glucose (SMBG) Pancreatitis Decoding HbA1c Test for Blood Sugar Hunger Fullness and Weight Control Carbohydrates and Its Role in Obesity 

Recommended Reading
Tips for Diabetics to Stay Healthy During Holiday Season
A Little of extra planning and self-care tips can keep diabetes under control during holiday ......
Painful Pinpricks Could be History for Diabetics
It is possible for diabetics to produce their own insulin, which will make the daily insulin ......
One-Fourth Diabetics of the World Live in China, but Care Could Improve
Diabetes, a major public health crisis in China, could incur an annual projected cost of 360 ......
Diabetics Hardly Pay Attention to Salt Warnings: Study
Despite knowledge that a high salt diet is linked to high blood pressure and stroke, it was not a .....
Carbohydrates and Its Role in Obesity
Obesity is a global epidemic with majority of the world’s population in developed countries being ov...
Decoding HbA1c Test for Blood Sugar
The HbA1c assay is the gold-standard measurement of chronic glycemia and measures the amount of gluc...
Diabetes - Essentials
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels a...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Hunger Fullness and Weight Control
An erratic way of eating or any metabolic disturbance in the hunger fullness signals is one of the m...
Otitis Media
Middle ear infection, or otitis media, is a common type of infection that may or may not accompany t...
Pancreatic Cancer
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. ...
Pancreatitis
Pancreatitis or inflammation of the pancreas may show up as acute pancreatitis or chronic pain. Alco...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use