Trajectories Of Antidepressant Usage During Pregnancy

More than half of the pregnant women stopped their antidepressant medications abruptly, a quarter maintained their medications throughout pregnancy, and one-fifth discontinued it for a minimum of three months and then resumed it during the postpartum period, according to a new analysis. The analysis, which is published in the British Journal of Clinical Pharmacology, included all pregnant women with information in the General Sample of Beneficiaries database affiliated with the French Health Insurance System, from 2009 to 2014.

The researchers noted that no sociodemographic or medical characteristics were associated with any trajectory group. Women who continued antidepressant treatment tended to have more frequent obstetric complications and postpartum psychiatric disorders.

Among women who interrupted treatment, prescription of benzodiazepines and anxiolytics decreased initially but rose postpartum to a higher level than before pregnancy.

"Monitoring the pregnancy of women taking antidepressants requires a lot of attention. It is important to assess the appropriateness of treatment at the time of pregnancy announcement and to monitor for psychiatric symptoms throughout pregnancy when treatment has been stopped," said senior author Catherine Laporte, MD, PhD, of the Université Clermont Auvergne, in France.

"General practitioners are very often called upon for non-obstetric health problems during pregnancy, so they must be made aware."

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Source-Eurekalert