About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

To Promote Peripheral Nerve Regeneration, NRG1 Isoforms Could Be An Effective Therapeutic Candidate

by Bidita Debnath on July 27, 2014 at 11:39 PM
Font : A-A+

 To Promote Peripheral Nerve Regeneration, NRG1 Isoforms Could Be An Effective Therapeutic Candidate

Neuregulin 1 (NRG1) is a pleiotropic factor, which is characterized by the existence of numerous isoforms arising from alternative splicing of exons that confer to the protein deeply different characteristics.

NRG1 plays an important role for both the myelination occurring during development and the different phases occurring after injury in the peripheral nerve: axon degeneration, axon regrowth, remyelination and target reinnervationResearchers at the University of Western Australia have discovered that the soluble NRG1 upregulation observed in Schwann cells immediately after nerve injury suggests that denervated Schwann cells require autocrine stimulation with soluble NRG1 for survival and that the peripheral nerve regeneration impairment observed in animals lacking Schwann cell derived soluble NRG1 is the indirect consequence of problems occurring during the early phases of axon degeneration and axon regrowth, not during the following phases of remyelination and target reinnervation.

Advertisement

These observations suggest that soluble NRG1 plays a role during the early phases following nerve injury corresponding to axon degeneration and regrowth, while transmembrane NRG1 plays a role during later phases corresponding to the remyelination process.

Therefore, soluble NRG1, already used in human trials for heart failure treatment, could be an effective therapeutic candidate to promote nerve regeneration. The Perspective article is released in Neural Regeneration Research (Vol9, No. 12, 2014)

Source: Eurekalert
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

To Promote Peripheral Nerve Regeneration, NRG1 Isoforms Could Be An Effective Therapeutic Candidate Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests