About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Tiny Sacs Released By Cancer Cells May Offer Effective Cure for Brain Tumour

by VR Sreeraman on November 18, 2008 at 2:47 PM
Font : A-A+

 Tiny Sacs Released By Cancer Cells May Offer Effective Cure for Brain Tumour

Massachusetts General Hospital (MGH) researchers say that brain tumour cells release tiny sacs called microvesicles, which contain information that may prove helpful in developing an effective treatment for the disease.

The researchers claim that they have found tumour-associated RNA and proteins in membrane microvesicles called exosomes in blood samples from glioblastoma patients.

Advertisement

Upon deeply analysing exosome contents, say the researchers, they could identify factors that could facilitate a tumour's growth through delivery of genetic information or proteins, or signify its vulnerability to particular medications.

"Glioblastomas release exosomes in sufficient quantities to pass the blood-brain barrier. We were able to isolate them, analyze the RNA transcripts and show how they might be used as biomarkers to guide targeted therapy and monitor treatment response," Nature Cell Biology quoted Dr. Johan Skog, who works in the laboratory of Dr. Xandra Breakefield at the MGH Neuroscience Center, as saying.
Advertisement

"Exosomes also may someday be used to deliver therapeutic molecules to the site of a tumour," added the study's lead author.

The research team claim that they are the first to carefully analyse the contents of exosomes shed from glioblastoma cells, and characterize their contents.

During the study, the researchers first analysed tumour cells from three glioblastomas, and verified that the cells released exosomes containing RNA and protein molecules.

The team observed that some messenger RNAs related to activities like cell proliferation and migration, angiogenesis, and immune response were highly abundant in the exosomes.

Upon culturing glioblastoma exosomes with normal cells, they saw that tumour RNA was delivered into the normal cells and generated its encoded protein, supporting the role of exosome-delivered RNA in manipulating the cellular environment.

The researchers then analysed tumour tissue and blood serum from 25 glioblastoma patients to determine the potential of glioblastoma exosomes as markers of a tumour's genetic makeup.

They said that their efforts enabled them to find tumour exosomes and to identify, in some tissue samples, a mutation in the epidermal growth factor receptor (EGFR) gene that characterizes a tumour subtype.

The group revealed that in two patients, an EGFR mutation that did not appear in the tumour tissue sample was identified by exosome analysis, reflecting how a surgical biopsy could miss tissue conveying critical information because of the often-chaotic diversity of cells within a tumour.

"It is known that the effects of some anticancer drugs depend on a tumor's genetic mutational profile, so our results have broad implications for personalized medicine," says Skog, who is an instructor in Neurology at Harvard Medical School.

"Detecting mutational profiles through a noninvasive blood test could allow us to monitor how a tumor's genetic makeup changes in response to therapy, which may necessitate changes in treatment strategy," he adds.

The researchers are currently researching into the role of exosomes in other solid tumours. Their aim is to find out how exosomes may help monitor additional tumour-associated mutations.

Source: ANI
LIN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Cancer and Homeopathy Parkinsons Disease Surgical Treatment Colorectal Cancer Cysts and Tumours Cancer Facts Cancer Brain Tumor Markers For Cancer Diagnosis and Prognosis Brain Facts 

Recommended Reading
Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors ....
Top Ten Facts About Brain Tumors
Quick valuable reference that enlists interesting facts about brain tumors....
Glioma Brain Tumor
Democrat Senator Edward Kennedy has been diagnosed with Glioma, a kind of brain tumor. Tests ......
Tumor Cells can Be Killed With Nanoparticles and Light Combo
University of Virginia medical physicists have come up with a new idea to kill tumour cells with ......
Colorectal Cancer
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third...
Cysts and Tumours
Ultrasound scan reveals multiple cysts and there is no function on that kidney when tested on DMSA s...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Tumor Markers For Cancer Diagnosis and Prognosis
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use