Time of the Day Impacts the Effectiveness of COVID-19 Treatment

Administering anti-inflammatory medications such as ibuprofen for COVID-19 during the right time of the day could positively impact the bodies response to the drug, according to a new study.

The review report is published in the //British Journal of Pharmacology .

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‘Anti-inflammatory drugs could be most beneficial when administered in the midafternoon of the day. They can strengthen the inflammatory response to fight against COVID-19.’
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The researchers wanted to understand why the anti-inflammatory drug ibuprofen was beneficial to some people but had negative effects on others.

The researchers dug deep into the idea of chronotherapy to understand the differences in the effects of ibuprofen.

Chronotherapy is a time-controlled treatment that is generally used to treat those with circadian rhythm-related disorders such as jet lag, irregular sleep-wake disorder or shift work sleep disorder.

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The goal of chronotherapy is to align the circadian clock to the preferred 24-hour cycle.

The optimal time for the use of certain medication can be targeted by taking the circadian rhythm into account.

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The researchers looked into literature that suggests how the administration of anti-inflammatory drugs given at a certain time of day would strengthen the inflammatory response, like lung inflammation in COVID-19 patients, which is often detrimental to the body.

"When you have chronic inflammation or a serious disease, there is a high chance that the circadian rhythm is disturbed. The circadian clock regulates how the body responds to an illness, such as COVID-19, by controlling the timing of inflammation," Seung-Hee Yoo said.

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The researchers concluded that anti-inflammatory agents are most effective when administered during the midafternoon.

The immune cells release cell signals associated with negative effects to the body during the mid-to-late afternoon.

So, this therapeutic window would be an effective time to allow the immune cells to produce inflammatory molecules to fight the virus.

Using chronotherapy to regulate the body's circadian rhythm while administering anti-inflammatory drugs like ibuprofen or dexamethasone in COVID-119 patients may have a significant impact that could help speed up recovery or prevent long-term effects.

Source-Medindia