About My Health Careers Internship MedBlogs Contact us

Successful Clinical Trials For New Rheumatoid Arthritis Drug

by Tanya Thomas on June 29, 2009 at 10:47 AM
Font : A-A+

 Successful Clinical Trials For New Rheumatoid  Arthritis Drug

Researchers have found that a new drug in development for the treatment of rheumatoid arthritis has been found to be well tolerated and effective in a clinical trial.

The trial of the drug called masitinib was carried out by researchers from several French hospitals. It involved 43 patients with arthritis resistant to current treatments.


Reporting their findings in BioMed Central's open access journal Arthritis Research and Therapy, the researchers have revealed that treatment with masitinib significantly reduced the severity of active arthritis.

"In choosing which interventions to use for the management of rheumatoid arthritis, it is important to recognise that treatment should aim to keep the disease in remission and not be used intermittently to manage exacerbations. We are encouraged from this study that masitinib not only appears to be effective, but that within the first 3 months of treatment the worst of its side-effects were over, possibly making it suitable for long-term treatment regimens," said Olivier Hermine, one of the researchers.

"The results of this study also help establish the critical role of mast cells in the pathogenesis of rheumatoid arthritis and demonstrate their viability as a therapeutic target. There is sufficient compelling evidence to warrant further placebo-controlled investigation," he added.

The researchers have revealed that masitinib inhibits the activity of mast cells, a component of the immune system thought to be involved in the pathogenesis of rheumatoid arthritis.

The clinical improvement described in the study was supported by laboratory evidence of reduced inflammation.

The authors found that adverse effects of the treatment were mainly mild to moderate.

Alain Moussy from AB Science, a pharmaceutical company who are developing masitinib for multiple indications in human and animal medicine, said: "This is a milestone article for us, being the first publication of masitinib in a human study."

Moussy added: "Our preclinical studies have shown that masitinib selectively targets cell receptors known to be involved in various disease processes but does not affect those associated with toxicity, particularly cardiotoxicity."

Source: ANI

News A-Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Osteoarthritis Rheumatoid Arthritis Clinical Trials Clinical Trials - The Past and The Future Clinical Trials - Different Phases of the trial Oligoarthritis Spondylolisthesis Signature Drug Toxicity Knee Replacement 

Recommended Reading
Severity Of Rheumatoid Arthritis Is Worse In Winter Or Spring Than In Summer
Rheumatoid arthritis (RA) patients who had the disease's symptoms in winter or in spring have more ....
63 Percent Of Rheumatoid Arthritis Patients Suffer From Psychiatric Disorders
Over half (63%) of patients with rheumatoid arthritis (RA) also suffer from psychiatric disorders....
Over Half Of People With Rheumatoid Arthritis Have Periodontitis
Over half (56%) of people with rheumatoid arthritis (RA) also have periodontitis....
Functional and Psychological Ability in Rheumatoid Arthritis Improved by Exercise
Undertaking a supervised exercise programme can have beneficial effects on functional status and ......
Clinical Trials
Clinical trials are experiments that yield useful information to clinicians if a particular treatmen...
Clinical Trials - Different Phases of the trial
Clinical trials serve as a vital component for improving the treatment of medical conditions as they...
Clinical Trials - The Past and The Future
Many of the drugs that are used today have been discovered by chance or often by mere serendipity...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Knee Replacement
Make sprinting a possibility! Relieve chronic arthritic pain by having a knee replacement done at ...
Most parents when told that their child has arthritis find it hard to believe it, as arthritis is re...
Osteoarthritis is one of the commonest joint disorder and occurs as we age due to wear and tear of a...
Rheumatoid Arthritis
Rheumatoid arthritis is a chronic inflammatory disease that causes pain, swelling, stiffness and los...
Spondylolisthesis is a condition of the lower spine in which one of the bones of the vertebral colum...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use