Medindia
Advertisement

Study Suggests Limiting Blood Flow Interruption During Kidney Surgery

by Kathy Jones on June 13, 2010 at 11:58 AM
Font : A-A+

 Study  Suggests Limiting Blood Flow Interruption  During  Kidney Surgery

Interrupting the blood flow for more than 20 to 25 minutes during kidney cancer surgery leads to a greater risk for patients developing chronic kidney disease, a Mayo Clinic and Cleveland Clinic collaborative research team has found.

For the retrospective study, researchers analyzed outcomes of 362 patients with only one kidney who underwent surgery for renal cortical tumors at Mayo Clinic and Cleveland Clinic between 1990 and 2008.

Advertisement

Using a technique called warm ischemia, surgeons kept the patient's kidneys at body temperature during the partial nephrectomy.

Ischemia involves cutting off the blood supply to the kidney with clamps in order to control bleeding and to keep blood from obscuring the surgeon's view of the kidney.
Advertisement

It also allows for precise closure of the urine collecting system and the surgical opening. The median ischemia time was 21 minutes in the study and the median age of patients was 62 years.

Ischemia can cause tissue damage from a lack of oxygen and nutrients. Researchers found that each additional minute of warm ischemia is associated with a 5 to 6 percent increase in the odds of developing acute renal failure or reduced kidney functioning and is associated with a 6 percent increased risk of new onset Stage IV chronic kidney disease during long-term follow-up.

"This is the largest evaluation of warm ischemia time in patients with a single kidney who are undergoing a partial nephrectomy, combining the experiences of the Mayo Clinic and Cleveland Clinic, both leaders in the field of kidney cancer," said R. Houston Thompson, Mayo Clinic urologist and the study's primary investigator.

"These results suggest that every minute counts when the renal arteries and veins are clamped. When planning for the surgery, surgeons should make efforts to minimize ischemia time, especially in situations where a person only has one kidney.

"Historically, 30 minutes was considered the maximum safe duration of warm ischemia during partial nephrectomy, and other retrospective clinical studies have suggested that warm ischemia for 40 to 55 minutes is safe. However, these studies included patients with two kidneys, which could mask the true effects of ischemia on renal function.

"Because each additional minute of warm ischemia invites the risk for chronic kidney problems, if longer ischemic times are unavoidable, techniques such as ice slush (cold ischemia) should be considered," Thompson added.

The researchers stressed that the study's results do not have implications for patients treated with cold ischemia.

The study was published today in the journal, European Urology.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis Blood in Stools - Symptom Evaluation 

Recommended Reading
Kidney Stones
A kidney stone is a solid mass made up of tiny crystals and may appear in any area of the urinary .....
Cysts and Tumours
Ultrasound scan reveals multiple cysts and there is no function on that kidney when tested on DMSA ....
Dialysis
Dialysis is an artificial process for removing excess water and waste from the blood. Hemodialysis ....
Diet for Kidney stones
Diet for kidney stone should comprise of calcium-rich foods, increased fluid intake. Other dietary ....
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Renal Tubular Acidosis
Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of...
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use