About Careers Internship MedBlog Contact us

Why Are You Jet Lagged?

by Dr. Trupti Shirole on March 11, 2015 at 4:58 AM
Why Are You Jet Lagged?

A study conducted by University of California, Irvine, reveals the inner mechanisms of jet lag with the help of first real-time imaging of intact circadian neural networks, courtesy of a fruit fly's 'brain in a jar'.

Researchers used imaging technology to make movies of fruit fly brains kept alive for 6-days in a petri dish. It captured the activity of individual circadian clocks at single-cell resolution with an extremely sensitive low-light camera. This showed how the circadian clock circuit is 'reset' by light.


The scientists found that desynchronization of circadian neurons is a key feature of light-induced jet lag. They suggest that treatments accelerating this desynchronization before travel may speed recovery afterward. Todd C. Holmes said, "Remarkably, our work indicates that the way you feel while jet-lagged exactly reflects what your nervous system is experiencing- a profound loss of synchrony."

Holmes explained that a single light pulse cues the biological clock of the fruit fly brain to shift two hours ahead of its original schedule through a process the researchers call 'phase retuning', which is characterized by a circadian circuit-wide pattern of brief desynchrony followed by the gradual emergence of a new state of network synchrony. The scientists propose that temporarily weakening synchronization among neurons governed by circadian patterns allows for more rapid adaptation, an estimated 2-days, by enabling phase retuning to a new time zone's cues.

The study appears online in Current Biology.

Source: Medindia
Font : A-A+



Latest Research News

Brain Circuits That Shape Bedtime Rituals in Mice
New study sheds light on the intrinsic, yet often overlooked, role of sleep preparation as a hardwired survival strategy.
NELL-1 Protein Aids to Reduce Bone Loss in Astronauts
Microgravity-induced bone loss in space, can be reduced by systemic delivery of NELL-1, a protein required for bone growth and its maintenance.
Connecting Genetic Variants to the Alzheimer's Puzzle
Researchers establish connections between Alzheimer's-linked genetic alterations and the functioning of brain cells.
Gene Therapy Sparks Spinal Cord Regeneration
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury.
Unlocking the Gut Microbiome's Influence on Bone Density
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Why Are You Jet Lagged? Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests