Researchers at McGill University have found new evidence that underlines the major role played by the nervous system and nerve-growth factor (NGF) in arthritis, a new study published in the Journal of Neuroscience reveals.
The findings also support the idea that reducing elevated levels of NGF - a protein that promotes the growth and survival of nerves, but also causes pain -- may be an important strategy for developing treatment of arthritis pain.
Using an approach established by arthritis researchers elsewhere, the McGill scientists examined inflammatory arthritis in the ankle joint of rats. In particular, they investigated changes in the nerves and tissues around the arthritic joint, by using specific markers to label the different types of nerve fibres and allow them to be visualized with a fluorescence microscope.
Normally, sympathetic nerve fibres regulate blood flow in blood vessels. Following the onset of arthritis in the rats, however, these fibres began to sprout into the inflamed skin over the joint and wrap around the pain-sensing nerve fibres instead. More sympathetic fibres were detected in the arthritic joint tissues, as well.
The results also showed a higher level in the inflamed skin of NGF - mirroring the findings of human studies that have shown considerable increases in NGF levels in arthritis patients.
To investigate the role of these abnormal sympathetic fibres, the McGill researchers used an agent to block the fibres' function. They found that this reduced pain-related behaviour in the animals.
"Our findings reinforce the idea that there is a neuropathic component to arthritis, and that sympathetic nerve fibres play a role in increasing the pain," said McGill doctoral student Geraldine Longo, who co-authored the paper with Prof. Afredo Ribeiro-da-Silva and postdoctoral fellow Maria Osikowicz.
"We are currently using drugs to prevent the production of elevated levels of NGF in arthritic rats; we hope that our research will serve as a basis for the development of a new treatment for arthritis in the clinic", said Prof. Ribeiro-da-Silva.