It is common knowledge among the medical community that catheter-related bacteremia can be a significant cause of sickness and death for hemodialysis patients. The anticoagulant heparin is commonly used as a catheter lock solution to prevent thrombosis; however has limited antimicrobial activity. Click image to Play Video To watch the video online, please install Quick Time Player Click here to download the player In a research study presented at this year''s Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), a team led by Professor Markus Nagl, M.D. at the Medical University of Innsbruck and Dr. Mark Anderson CSO at NovaBay Pharmaceuticals evaluated the effect of three compounds on the blood coagulation pathways. The compounds evaluated were N-chlorotaurine (NCT) produced by human phagocytes as part of the innate immune system''s response to pathogens; and two NCT analogs NVC-612 and NVC-422. All three agents have broad-spectrum antimicrobial activity, and exhibit anticoagulation activity. These activities allow for their possible use as catheter lock solutions. Dr. Anderson stated: "The use of therapeutic catheter lock solutions containing antimicrobial agents, either alone or in combination with anticoagulant agents, may be an important addition for the prevention of intravascular catheter-related bacteremia." The research team found that at specific concentrations of NCT, NVC-612 and NVC-422, prothrombin time was extended by 17-30%; activated partial thromboplastin time was extended 3-fold to 4-fold; and thrombin time was extended 2-fold to 4-fold. Furthermore, fibrinogen decreased from 258-283 mg/dL to less than 40 mg/dL in certain samples; direct thrombin inhibition was not observed. Therefore, these compounds could serve as promising candidates for potential use as broad-spectrum antimicrobials for catheter lock solutions with anticoagulant properties. Source: Newswise << Promising Techniques for Extending the Life of an Organ Tra... Research Highlights Novel Infected Tissue Model for Pre-Cli... >> Recommended Reading Dialysis Dialysis is an artificial process for removing excess water and waste from the blood. Hemodialysis and peritoneal dialysis are the types of dialysis. READ MORE Azad to Inaugurate Standalone Dialysis Unit at CGHS Clinic in Delhi In a pioneering initiative and first of its kind in CGHS Ghulam Nabi Azad will inaugurate a standalone haemodialysis centre CGHS Wellness centre in Delhi today. READ MORE Researchers Find Suffering Caused by Dialysis for Nursing Home Seniors may Outweigh Its Benefits Researchers at the Stanford University School of Medicine say that older Americans living in nursing homes experience inability to do routine tasks after dialysis READ MORE Anticoagulants Anticoagulants prevent the clotting of blood in our body. They are administered orally or via injection. READ MORE Food Preservatives - How Safe Are They? Food preservatives are basically antimicrobials or anti-oxidants that help preserve food by destroying the microbes and stopping decomposition of food products. READ MORE Most Popular on Medindia A-Z Drug Brands in India Color Blindness Calculator Vent Forte (Theophylline) More News on: AnticoagulantsFood Preservatives - How Safe Are They?