Chronic periods of stress can be detrimental to health by increasing inflammation and promoting the progression of diseases including cancer. A new study published in the Journal Nature Communications revealed that chronic stress can impact functioning of lymphatic system triggering cancer metastasis. The lymphatic system helps carry immune cells through the body to fight illness, but it could also play a role in transporting cancer cells through the body. ‘Chronic stress remodels tumor-associated lymphatic architecture to promote lymph node metastasis.’ Researchers at the Melbourne's Monash University conducted a study on mice with cancer. They examined whether stress can influence cancer spread to other parts of the body. They found that high levels of stress triggers the production of adrenaline by the activation of sympathetic nervous system (SNS) that causes large amount of fluids to enter into the lymphatic system. The entry of fluids causes the lymphatic system to expand, resulting in high fluid inflow and outflow. The researchers describe this mechanism as "lymphatic highway" which influences the cancer cells to spread through the body. Adrenaline not only increases the number of lymphatic vessels draining from the tumor but also increase the flow in existing vessels. "We found that chronic stress activates the sympathetic nervous system (SNS) — better known as the 'fight-or-flight' response — to profoundly impact lymphatic function and the spread of cancer cells. These findings demonstrate an instrumental role for stress and suggest that blocking the effects of stress to prevent cancer spread through lymphatic routes may provide a way to improve outcomes for patients with cancer," said Dr. Caroline Le, one of the study's lead researchers. Once researchers found that stress induces the production of adrenaline, they went on to see whether blocking the adrenaline production through a commonly used blood pressure drug can prevent cancer metastasis. The drug propanol was used on stressed mice with breast cancer. They found that the drug stopped their stress hormones from remodeling the lymph vessels inside the tumor, and reduced the risk of cancer spreading through the lymphatic system. Reference: Caroline P. Le, Erica K. Sloan et al. Chronic stress in mice remodels lymph vasculature to promote tumor cell dissemination, Nature Communications 2016, doi:10.1038/ncomms10634. Source: Medindia << Genes That Lead to Gray Hair And Monobrow Identified UK Initiates Phase I Trial of Immunotherapy for Advanced Can... >> Recommended Reading Environment of Tumors Has a Significant Impact on Cancer Metastasis Researchers have explained that if a tumor is like a seed, the soil around it plays a significant role in its growth. READ MORE Cancer Metastasis May be Suppressed by Knocking Down a Key Protein Ninety-five percent of all cancer deaths are due to metastasis and not due to the primary cancer. READ MORE Expression Of ALK1 Protein May Play a Role in Detecting Cancer Metastasis The presence of high levels of ALK1 in the breast tumor vasculature is a prognostic biomarker for the metastatic disease in mice. READ MORE Cytosine Deamination Could be the Reason Behind Malignant Tumors The APOBEC family of enzymes plays an important role in the human immune system by driving changes in immune cells that aid in defense against viruses. READ MORE Andropause / Male Menopause Andropause or male menopause causing low libido in a man is due to decreasing level of male hormones, like testosterone. Symptoms of andropause are depression, irritability. READ MORE Heart Attack- Lifestyle risks Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed. READ MORE Is Your Man Moody? Women get confused by the behavior of men in their lives. It is time they realize that men too have frequent mood swings. READ MORE Palpitations And Arrhythmias Palpitations are unpleasant sensation of one’s own heartbeat. READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Tattoos A Body Art Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look READ MORE Most Popular on Medindia Pregnancy Confirmation Calculator Sanatogen Find a Doctor More News on: Cancer and HomeopathyPalpitations And ArrhythmiasStress Relief Through Alternative MedicineStress and the Gender DivideCancer FactsAndropause / Male MenopauseCancerTattoos A Body ArtHeart Attack- Lifestyle RisksIs Your Man Moody?