About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Simple Quick Test to Diagnose Ulcerative Colitis

by Julia Samuel on April 27, 2016 at 5:18 PM
Font : A-A+

Minimal invasive screening for ulcerative colitis using infrared technology could be a rapid and cost-effective method for detecting disease.

The technique eliminates the need for biopsies and intrusive testing of the human body and involves testing serum, the clear liquid that can be separated from clotted blood, for the increased presence of mannose, a sugar that is a marker for colitis, using Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy. This technology is sensitive to vibrations in the chemical bonds of the serum sample's molecules and requires minimal sample preparation, making it a rapid diagnostic alternative.

Advertisement

Simple Quick Test to Diagnose Ulcerative Colitis
Simple Quick Test to Diagnose Ulcerative Colitis

"We found that ATR-FTIR spectroscopy is an effective tool for detecting colitis in the serum of mice," said Unil Perera, a Regents' Professor of Physics and researcher in the Center for Nano-Optics at Georgia State.

"This rapid, simple, cost-effective and minimally invasive technique could be further developed into a personalized diagnostic tool that would assess disease status based on an individual's molecular composition and allow for personalized diagnosis and drug management. Perhaps this technology could be integrated into a portable device, such as the glucometer used by patients with diabetes."
Advertisement

Inflammatory bowel diseases, which include ulcerative colitis and Crohn's disease, involve chronic inflammation of all or part of the digestive tract and can lead to life-threatening complications such as colorectal cancer.

Assessing this inflammation remains a challenge, and clinical diagnosis is now achieved by colonoscopy, which uses an endoscope or flexible tube with a light and camera attached to examine the digestive tract. This technique is not ideal for an annual checkup or monitoring disease activity regularly because it's expensive, invasive and requires sedation.

As a result, "there is a need for a simple, inexpensive and low-risk diagnostic tool for inflammatory bowel diseases," said Didier Merlin, professor in the Institute of Biomedical Sciences at Georgia State and a researcher at the Atlanta Veterans Affairs Medical Center. "Infrared spectroscopy has greatly enhanced clinical medicine in the last two decades and shows promise as a solution."

In the study, mice in two categories were tested for colitis using ATR-FTIR spectroscopy. The first group was mice with targeted deletion of the interleukin 10 (IL10) gene, known as interleukin 10 knockout (IL10-/-) mice, which develop colitis through T helper immune cells. Disease in IL10-/- mice closely resembles the physiological, histological and biochemical features of chronic colitis in humans.

In the second group of mice, colitis was induced by administering Dextran Sodium Sulphate. Colitis in these mice is similar to ulcerative colitis in humans. In both groups, feces and blood samples were collected and tested. Mice in control groups were also tested.

The researchers found ATR-FTIR spectroscopy is an effective tool for detecting colitis in mice serum, showing a significant increase in the levels of mannose, an indicator of colitis. The Georgia State University Research Foundation has filed a provisional patent for the screening technique.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Varicocele Ulcerative Colitis Autoimmune Disorders Digestive Tract Ulcers Symptom Evaluation Testicle Pain - Symptom Evaluation Ileostomy Inflammatory Bowel Disease 

Most Popular on Medindia

Selfie Addiction Calculator Post-Nasal Drip Sanatogen Drug - Food Interactions Vent Forte (Theophylline) Pregnancy Confirmation Calculator A-Z Drug Brands in India Nutam (400mg) (Piracetam) Turmeric Powder - Health Benefits, Uses & Side Effects Accident and Trauma Care
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Simple Quick Test to Diagnose Ulcerative Colitis Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests