Women suffer from a higher incidence of chronic and inflammatory
pain conditions such as fibromyalgia and osteoarthritis. While morphine
continues to be one of the primary drugs used for the treatment of
severe or chronic pain, it is often less effective in females.
A female brain's resident immune cells are more active in regions involved in pain processing relative to males, observed a recent study by Georgia State University researchers.
The study, published in the Journal of Neuroscience, found that when microglia, the brain's resident immune cells, were blocked, female response to opioid pain medication improved and matched the levels of pain relief normally seen in males.
In healthy individuals, microglia survey the brain, looking for signs of infection or pathogens. In the absence of pain, morphine interferes with normal body function and is viewed as a pathogen, activating the brain's innate immune cells and causing the release of inflammatory chemicals such as cytokines.
To test how this sex difference affects morphine analgesia, Doyle gave male and female rats a drug that inhibits microglia activation.
"The results of the study have important implications for the treatment of pain, and suggests that microglia may be an important drug target to improve opioid pain relief in women," said Dr. Anne Murphy, co-author on the study and associate professor in the Neuroscience Institute at Georgia State.
The research team's finding that microglia are more active in brain regions involved in pain processing may contribute to why the incidence rates for various chronic pain syndromes are significantly higher in females than males.