About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Identify Possible Culprit Behind Eczema and Allergic Skin Diseases

by Sheela Philomena on April 24, 2013 at 11:06 AM
Font : A-A+

 Scientists Identify Possible Culprit Behind Eczema and Allergic Skin Diseases

Scientists have discovered a possible culprit behind eczema and allergic skin diseases.

Researchers from the Immune Imaging and T cell Laboratories at the Centenary Institute worked with colleagues from SA Pathology in Adelaide, the Malaghan Institute in Wellington, New Zealand and the USA.

Advertisement

The new cell type is part of a family known as group 2 innate lymphoid cells (ILC2), which was discovered less than five years ago in the gut and the lung, where it has been linked to asthma.

But this is the first time such cells have been found in the skin, and they are relatively more numerous there.

"Our data show that these skin ILC2 cells can likely supress or stimulate inflammation under different conditions. They also suggest a potential link to allergic skin diseases," said Dr Ben Roediger, a research officer in the Immune Imaging Laboratory at Centenary headed by Professor Wolfgang Weninger.
Advertisement

The Weninger lab, which has developed techniques for marking different cells of the immune system and tracking them live under the microscope, actually discovered the new dermal cells some years back.

The Centenary researchers, however, suspected they might be associated with type 2 immunity, the part of the immune system that deals with infection by parasitic organisms. So they contacted Professor Graham Le Gros at the Malaghan Institute, one of the world's foremost researchers into type 2 immunity.

Not only did Professor Le Gros and his team confirm that the Centenary researchers had found a new form of ILC2 cell, but they were able to provide a new strain of mouse developed in the USA that provided insight into the function of these cells.

"Using these mice, we found that ILC2 cells were the major population in the skin that produced interleukin 13, a molecule that has been linked to a number of allergic diseases, including eczema." Roediger said.

Using their sophisticated live imaging techniques, the Centenary researchers were also able to watch the behaviour of the ILC2 cells in the skin, where they moved in a characteristic way-in random spurts punctuated by stoppages.

"A halt in movement usually indicates some sort of interaction with another cell," Roediger said.

In this case, the ILC2 cells always seemed to stop in close proximity to mast cells, which are known to play a key role in controlling parasitic infections and to be associated with allergies.

As well as the interaction with mast cells, the Centenary team were able to show that ILC2 cells could be stimulated to spread quickly and were capable of generating the inflammatory skin disease.

The findings have been published today in the respected journal Nature Immunology.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Is COVID-19 Vaccination during Pregnancy Safe?
Sensory Processing Disorder (SPD)
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Allergy Skin Disorder Atopic Dermatitis Boils / Skin Abscess Skin Disease Pityriasis rosea Pemphigus Hives Scleroderma Types of Food Allergies 

Recommended Reading
Atopic Dermatitis
Atopic dermatitis is an inflammatory, non-contagious, chronic skin disorder that involves scaly and ...
Skin Disease
Skin diseases also known as dermatologic disorders are many in number and so are their causes. The ....
Quiz on Allergy
Every season can be an allergy season, depending on what you're allergic to. - Clara ......
Quiz on Skin
How much do you know about the human skin? Please take this quiz and find ......
Allergy
An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic react...
Boils / Skin Abscess
Encyclopedia section of medindia gives general info about Boils / Skin Abscess ......
Hives
Hives or Urticaria are allergic skin reaction that appear suddenly in clusters or as single bumps on...
Pemphigus
Pemphigus is a rare group of autoimmune diseases that affect the skin and mucous membranes causing b...
Pityriasis Rosea
Pityriasis rosea is a common skin disease that is not contagious. It manifests as oval-shaped, pink ...
Scleroderma
Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibro...
Skin Disorder
Skin types can range from oily to dry, extreme dryness accompanied by rashes and itching can often d...
Types of Food Allergies
If you are allergic to certain food items-Watch out for what you ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use