About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Identify New Genetic Variant Linked to Onset of Prostate Cancer

by Rajashri on September 3, 2008 at 11:13 AM
 Scientists Identify New Genetic Variant Linked to Onset of Prostate Cancer

A new variant in the gene HNF1B, responsible for developing prostate cancer has been identified by scientists from Wake Forest University School of Medicine.

The research team has reported the discovery of a second independent site within the HNF1B gene on chromosome 17 (17q12), thus increasing the number of genetic variants that may contribute to risk of developing the disease.

Advertisement

Jianfeng Xu, M.D., Dr. Ph.H, senior researcher on the study and a professor of epidemiology and cancer biology and Director of the Center for Cancer Genomics then compared the newly discovered site with the site discovered earlier in the same gene and said, "these data strongly suggest that the two sites are genetically independent.

"We found another genetic variant associated with prostate cancer risk," Nature Genetics quoted Xu, as saying.

"The more genetic variants we discover, the better off we are. As we find more of these, it improves our ability to predict prostate cancer risk," Xu added.
Advertisement

In the study what the researchers called a "fine-mapping study" two groups were studied, one called CAPS, from Sweden, that had 2,899 prostate cancer cases and 1,722 control participants, and the Johns Hopkins study that had 1,527 prostate cancer patients and 482 control participants.

They identified two separate clusters of prostate-cancer-associated SNPs (single nucleotide polymorphisms), one in a region previously identified and one in a new region.

To understand, whether the genetic variants were linked to prostate cancer the team analysed the same locations in five other large studies of prostate cancer patients.

The analysis showed that prostate cancer risk was higher among men who had the genetic variants.

Previous studies have also shown that a man with four of the five already discovered variants has a 400 percent increased risk of developing prostate cancer compared to men with none of the variants.

he findings appear in current on-line version of Nature Genetics.

Source: ANI
RAS/M
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Genetics & Stem Cells News

Gene Therapy Breaks Up New Dawn for Beta Thalassemia
Groundbreaking gene therapy for genetic beta thalassemia is now accessible as a treatment to a patient post-FDA approval.
Scientists Uncover Stem Cells in the Thymus for the First Time
Thymic stem cells actively participate in their environment by generating extracellular matrix proteins, essentially forming their own support system.
First Allogenic Stem Cell Transplant
Scientists aspire to utilize stem cell transplantation for pediatric patients grappling with blood-related conditions like aplastic anemia, and thalassemia.
Scientists Accomplish Complete Genome Sequencing of Y Chromosome
Researchers have sequenced male Y chromosomes, yielding a comprehensive blueprint of the entire human chromosome collection.
Cell Therapy for Cornea Damage Addressed by Patient's Own Stem Cells
CALEC (Cultivated autologous limbal epithelial cells) procedure for stem cell transplant in eye procedures is safe and feasible, showing improved corneal surfaces or vision.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Scientists Identify New Genetic Variant Linked to Onset of Prostate Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests