Medindia
Advertisement

Scientists Identify Genes Linked to Throat Cancer

by Thilaka Ravi on May 31, 2010 at 7:03 PM
Font : A-A+

 Scientists Identify Genes Linked to Throat Cancer

Scientists have identified genes associated with throat cancer.

Genome Institute of Singapore and Sun Yat-Sen University Cancer Centre identified the three new susceptibility genes.

Advertisement

The study, led by the Genome Institute of Singapore (GIS), a biomedical research institute of the Agency for Science, Technology and Research (A STAR), and the Sun Yat-Sen University Cancer Centre, identified genetic risk factors of NPC that advance the understanding of the important role played by host genetic variation in influencing the susceptibility to this cancer.

NPC is a type of cancer that forms in the epithelial lining of the nasopharynx, the area of the upper throat that lies behind the nose. It is particularly prevalent in southern China, such as Guangdong, with an occurrence rate of about 25 times higher than that in most regions of the world.
Advertisement

NPC is therefore referred to as the Cantonese Cancer (Cantonese is a Chinese dialect spoken in and around the city of Guangzhou in Southern China).

To search for the genetic risk factors for NPC, the scientists carried out a comprehensive genetic analysis of the human genome in a large clinical sample of southern Chinese descent - approximately 5,000 patients and 5,000 controls.

The researchers found that the genetic variation within the human leukocyte antigen (HLA) [1] and the three genes known as TNFRSF19, MDSIEVI1 and CDKN2A/2B can significantly influence a person's risk of developing NPC.

The researchers also noticed that these three susceptibility genes for NPC have been reported to be involved in the development of leukemia, suggesting there might be some shared biological mechanism between the developments of these two diseases.

This finding provides an important opportunity for biologists to understand the molecular mechanism underlying the development of this cancer, and its unusual pattern of high prevalence in southern China.

Co-lead author Dr Liu Jianjun said: "Although many groups have attempted to identify the genetic risk factors of NPC, the findings of previous studies were limited by the small number of genes and clinical samples used. Because of this large-scale study of approximately 10,000 subjects in total, we are able to break through with more robust evidence compared to previous studies."

Co-lead author Prof Zeng added, "This finding confirmed the strong genetic effect of HLA locus in the risk of NPC. By using the high density of genetic markers, our finding helps to narrow down the chromosome region to search for the causative gene variant(s) associated with HLA loci. The identification of susceptibility genes involved in the risk of NPC will help to develop a model for risk prediction and then screen for high risk populations, which in turn will be helpful for early diagnosis of NPC."

The findings of the study have been published in Nature Genetics.

Source: ANI
THK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Laryngeal Cancer Weaver Syndrome Strep Throat Difficulty in Swallowing or Lump in the Throat (Dysphagia) Symptom 
Recommended Reading
Difficulty in Swallowing or Lump in the Throat (Dysphagia) Symptom
What are types of lumps in throat and what causes them? Can they be a sign or symptom of something m...
Laryngeal Cancer
Laryngeal cancer is also called cancer of the larynx or throat cancer or laryngeal carcinoma. It usu...
Strep Throat
Strep Throat is a bacterial infection caused by Group A beta hemolytic streptococci. It affects most...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use