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Scientists Create 3D Human Arrhythmic Tissue

by Savitha C Muppala on November 22, 2013 at 9:38 PM
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 Scientists Create 3D Human Arrhythmic Tissue

Scientists at the University of Toronto's Institute of Biomaterials & Biomedical Engineering (IBBME) and the McEwen Centre for Regenerative Medicine have made a breakthrough and created the first-ever living, three-dimensional human arrhythmic tissue.

Extensive research led them to successfully infer the exact type and ratio of cell types which can produce highly functional cardiac tissue.

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Electrical pulses were applied to the arrhythmic tissues to get the irregularly beating tissue into a state of regular contractions.

"Hearts are not just composed of one type of cell," said fourth-year IBBME PhD student Nimalan Thavandiran, who is the first author of the study.

Scientists have not been able to combine the many cell types in engineered heart tissue in a manner that the tissue achieves the composition and maturity level of the native human heart.
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Scientists cracked the problem by systematically sorting out different cell types taken from human pluripotent stem cells and mixing them together in a precise way.

"The composition of the cells is vital. We discovered that a mixture of 25 per cent cardiac fibroblasts (skin-like cells) to 75 per cent cardiomyoctes (heart cells) worked best," said Thavandiran.

"The carefully composed cell ratios were then grown in three-dimensional "wires" that mimic the structure of human heart tissue.An exciting result of our study is our ability to miniaturise the tissues into human heart micro-tissues that can be used to measure normal and diseased human heart responses to drugs," said Professor Peter Zandstra, who is part of the team that conducted the study.



Source: Medindia
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