High levels of the stress hormone cortisol strongly predict cardiovascular death among both persons with and without pre-existing cardiovascular disease, a new study has said.
In stressful situations, the body responds by producing the hormone cortisol. The effects of cortisol are intended to help the body recover from stress and regain a status of homeostasis, however chronically elevated cortisol levels have been associated with cardiovascular risk factors, such as the metabolic syndrome and accelerated atherosclerosis.
"Previous studies have suggested that cortisol might increase the risk of cardiovascular mortality, but until now, no study had directly tested this hypothesis," said Nicole Vogelzangs, of VU University Medical Center in The Netherlands and lead author of the study.
"The results of our study clearly show that cortisol levels in a general older population predict cardiovascular death, but not other causes of mortality."
In this study, researchers evaluated 861 people aged 65 years and older who participated in a prospective cohort study. Within six years of the beginning of the study 183 participants had died.
Urinary cortisol levels of subjects were measured at the beginning of the study and cause of death was ascertained from death certificates.
Researchers found that urinary cortisol did not increase the risk of non-cardiovascular mortality but did increase cardiovascular mortality risk.
The third of the subjects with the highest urinary cortisol had a five-fold increased risk of dying of cardiovascular disease.
The study has been accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM).