About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Try Modulating the Immune System to Combat Metastatic Cancer

by Rukmani Krishna on May 27, 2013 at 9:53 PM
Font : A-A+

 Researchers Try Modulating the Immune System to Combat Metastatic Cancer

By avoiding detection and destruction by the immune system, cancer cells spread and grow. Stimulation of the immune system can help to eliminate cancer cells; however, there are many factors that cause the immune system to ignore cancer cells. Regulatory T cells are immune cells that function to suppress the immune system response.

In this issue of the Journal of Clinical Investigation, researchers led by Ronald Levy at Stanford University found that regulatory T cells that infiltrate tumors express proteins that can be targeted with therapeutic antibodies. Mice injected with antibodies targeting the proteins CTLA-4 and OX-40 had smaller tumors and improved survival. Moreover, treatment with these antibodies cleared both tumors at the primary site and distant metastases, including brain metastases that are usually difficult to treat. These findings suggest that therapies targeting regulatory T cells could be a promising approach in cancer treatment.

Advertisement

In an accompanying commentary, Cristina Ghirelli and Thorsten Hagemann emphasize that in order for this approach to be clinically relevant, it will be important to show that targeting regulatory T cells in metastatic tumors also blocks growth.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Immunisation Cancer Facts Cancer Tattoos A Body Art Myasthenia Gravis Cytokines - Part of Body's Defence System 

Recommended Reading
In the War Against Cancer, Our Immune System is On Surveillance
For cancer patients, predicting outcomes based on tumor-immune system interactions is an emerging .....
Stem-cell-based Strategy Boosts Immune System in Mice: Researchers
UC San Francisco researchers have created the first functioning human thymus tissue from embryonic ....
Immune System in Females Ages More Slowly Than in Males
A new study suggests that the reason why women tend to live longer than men was because their ......
How Immune System Peacefully Co-exists With 'Good' Bacteria?
Commensal bacteria is loaded in the human gut - "good" microbes that, among other functions, help .....
Cytokines - Part of Body's Defence System
Cytokines are chemical signaling molecules produced by immune cells of our body and help cells in th...
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use