Researchers say that findings from a new study could serve as a springboard for the development of taste modulators to help control the appetite for a high-salt diet.
And it could also reduce the ill effects of too much sodium.
Drugs Causing Low Blood Sodium Levels / Hyponatremia
Many drugs can lower your blood sodium levels or hyponatremia. Low blood sodium symptoms are associated with salt level in blood and causes of hyponatremia are decrease in sodium and water content.
Advertisement
Charles Zuker, PhD, and colleagues at Columbia University Medical Center have discovered how the tongue detects high concentrations of salt, the first step in a salt-avoiding behavior common to most mammals.
The sensation of saltiness is unique among the five basic tastes. Whereas mammals are always attracted to the tastes of sweet and umami, and repelled by sour and bitter, their behavioral response to salt dramatically changes with concentration.
![Food Additives]( "Food Additives")
A food additive is a non-nutritive substance added deliberately to any food product to improve its color, texture, flavor or shelf life
"Salt taste in mammals can trigger two opposing behaviors. Mammals are attracted to low concentrations of salt; they will choose a salty solution over a salt-free one. But they will reject highly concentrated salt solutions, even when salt-deprived," said Dr. Charles Zuker, professor in the Departments of Biochemistry and Molecular Biophysics and of Neuroscience at Columbia University College of Physicians and Surgeons.
Over the past 15 years, the receptors and other cells on the tongue responsible for detecting sweet, sour, bitter, and umami tastes-as well as low concentrations of salt-have been uncovered largely through the efforts of Dr. Zuker and his collaborator Nicholas Ryba from the National Institute of Dental and Craniofacial Research.
"But we didn't understand what was behind the aversion to high concentrations of salt," said Yuki Oka, a postdoctoral fellow in Dr. Zuker's laboratory and the lead author of the study.
The researchers expected high-salt receptors to reside in cells committed only to detecting high salt.
"Over the years our studies have shown that each taste quality-sweet, bitter, sour, umami, and low-salt-is mediated by different cells. So we thought there must be different taste receptor cells for high-salt. But unexpectedly, Dr. Oka found high salt is mediated by cells we already knew," Dr. Ryba said.
In experiments conducted by Dr. Oka, the researchers found that high salt concentrations activate previously discovered bitter- and sour-sensing cells. When one of these cell types was silenced and made incapable of sending messages to the brain, aversion to high-salt solutions was reduced, but not eliminated.
When both cell types were silenced, the mammals completely lost their aversion to high-salt solutions, even showing unrestrained attraction to exceedingly salty solutions equivalent to those of seawater.
For mammals, ingesting high concentrations of seawater can lead to extreme dehydration, kidney failure, and death. With two aversion pathways, Dr. Oka said, animals have a safeguard to make sure that high salt is always aversive.
Now that all the salt pathways have been identified, Dr. Oka said, it may be possible to use that knowledge to make low concentrations of salt taste saltier, to reduce NaCl intake.
It also may be possible to make the taste of KCl (potassium chloride), which has fewer long-term health effects than sodium chloride, more appealing to encourage its use as a salt substitute.
The findings were published today online in Nature.
Source: ANI
Food Additives
A food additive is a non-nutritive substance added deliberately to any food product to improve its color, texture, flavor or shelf life
Advertisement
"Salt taste in mammals can trigger two opposing behaviors. Mammals are attracted to low concentrations of salt; they will choose a salty solution over a salt-free one. But they will reject highly concentrated salt solutions, even when salt-deprived," said Dr. Charles Zuker, professor in the Departments of Biochemistry and Molecular Biophysics and of Neuroscience at Columbia University College of Physicians and Surgeons.
Over the past 15 years, the receptors and other cells on the tongue responsible for detecting sweet, sour, bitter, and umami tastes-as well as low concentrations of salt-have been uncovered largely through the efforts of Dr. Zuker and his collaborator Nicholas Ryba from the National Institute of Dental and Craniofacial Research.
"But we didn't understand what was behind the aversion to high concentrations of salt," said Yuki Oka, a postdoctoral fellow in Dr. Zuker's laboratory and the lead author of the study.
The researchers expected high-salt receptors to reside in cells committed only to detecting high salt.
"Over the years our studies have shown that each taste quality-sweet, bitter, sour, umami, and low-salt-is mediated by different cells. So we thought there must be different taste receptor cells for high-salt. But unexpectedly, Dr. Oka found high salt is mediated by cells we already knew," Dr. Ryba said.
In experiments conducted by Dr. Oka, the researchers found that high salt concentrations activate previously discovered bitter- and sour-sensing cells. When one of these cell types was silenced and made incapable of sending messages to the brain, aversion to high-salt solutions was reduced, but not eliminated.
When both cell types were silenced, the mammals completely lost their aversion to high-salt solutions, even showing unrestrained attraction to exceedingly salty solutions equivalent to those of seawater.
For mammals, ingesting high concentrations of seawater can lead to extreme dehydration, kidney failure, and death. With two aversion pathways, Dr. Oka said, animals have a safeguard to make sure that high salt is always aversive.
Now that all the salt pathways have been identified, Dr. Oka said, it may be possible to use that knowledge to make low concentrations of salt taste saltier, to reduce NaCl intake.
It also may be possible to make the taste of KCl (potassium chloride), which has fewer long-term health effects than sodium chloride, more appealing to encourage its use as a salt substitute.
The findings were published today online in Nature.
Source: ANI
Reducing Salt Could Save Lives in US
According to a recent study published in Hypertension, less sodium in the U.S. diet could save 280,000 to 500,000 lives over 10 years.
Advertisement
 New Guidelines on Recommended Daily Limit for Salt Intake Issued by WHOThe World Health Organization has come out with new guidelines that slightly revise the recommended daily limit of salt intake among adults. | Advertisement
|
Advertisement
Recommended Readings
Latest Research News
New study sheds light on the intrinsic, yet often overlooked, role of sleep preparation as a hardwired survival strategy.
Microgravity-induced bone loss in space, can be reduced by systemic delivery of NELL-1, a protein required for bone growth and its maintenance.
Researchers establish connections between Alzheimer's-linked genetic alterations and the functioning of brain cells.
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury.
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
