Researchers Develop Ointment for Skin Cancer Prevention

by Mohamed Fathima S on July 3, 2019 at 1:44 PM
Font : A-A+

Researchers Develop Ointment for Skin Cancer Prevention

Researchers have developed an ointment that can prevent primary skin cancer and its recurrence. Based on the study published in Molecules, the ointment contains antisense oligonucleotides which are short DNA, RNA fragments used in oncology to suppress the synthesis of tumor proteins.

The role of antisense oligonucleotides is to support the functions of proteins responsible for apoptosis in the human body. This natural mechanism allows cells to carry out programmed death. As a result of skin exposure to primary damaging factors, such as ultraviolet (natural sunlight, tanning machines UV), these proteins may be restrained to function in the transformed cells, thus the regulation of apoptosis is violating, in some cases it becomes impossible. Due to this, the cells begin to divide uncontrollably and mutate resulting in the tumor occurrence.


The most reliable way to get rid of skin cancer is to cut it out surgically. However, at different stages of tumor progression, especially concerning the most aggressive and lethal types of skin cancer - melanoma and Merkel carcinoma - it's difficult to recognize the tumor boundaries and depth. Thus, for a surgeon, it's not clear how much tissues around a tumor area should be removed. The fact is that these tissues may hide isolated tumor cells, which may provoke the relapse of cancer in the future. To cope with that, we consider special ointments as promising treatment, which we suggest as an additional measure to surgical excision. Ointments will help patients to get free of some aesthetic defects that inevitably follow the surgery. In some cases, at the initial stages of the malignancy, ointment-based treatment, perhaps, will allow one to completely avoid the operation.' Vadim Kumeiko said, Deputy Director for Development, Head of Laboratory of Biomedical Cell Technologies, FEFU School of Biomedicine.

The researchers are focused on the development of an ointment containing antisense oligonucleotides for BCL-2 and survivin proteins. It will be designed to fight over melanoma, the most deadly type of skin cancer. The components of the ointment will penetrate the stratum corneum, and reach the melanocytes and progenitor cells, the mutation of which can lead to the development of a deadly tumor.

One of the main challenges in the development of such an ointment remains the speed of delivery of antisense oligonucleotides into cancerous tissues. These compounds are unstable and can lose their effectiveness even before they reach damaged skin cells. For the same reason, the strategy of direct topical application of the ointment at the area of the damaged cells seems to be more effective comparing to other delivering routes, for example, intravenous.

Skin cancer remains the most common type of malignancy. It accounts for one of the three cases of cancer diagnosed. Ultraviolet radiation of natural and artificial origin is one of the main factors affecting the mutation of human skin cells into tumor cells. As a rule, cancer occurs on the skin areas which are most often exposed to the natural sunlight or tanning machines UV. Men and women of different ages and skin color are vulnerable to skin cancer. In the high-risk group are the elderly, people with white or light-colored skin, with blue eyes, as well as redheads.

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Sedentary Behavior Precipitates Night-Time Hot Flashes
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Boils / Skin Abscess Skin Cancer Cancer and Homeopathy Ultra-Violet Radiation Cancer Facts Pityriasis rosea Cancer Tattoos A Body Art Pemphigus Hives 

Recommended Reading
Skin Cancer
Skin cancer is an abnormal growth of skin cells. It can develop due to a continuous exposure to sun ...
Basal Cell Cancer of the Skin
Basal cell cancer is a locally invading cancer. It often occurs on the face above a line joining ......
Epidermolysis Bullosa
People with epidermolysis bullosa (EB) develop skin blisters in response to minor injury. EB can ......
Melanoma is a dangerous form of skin cancer caused largely due to exposure to the sun's damaging UV ...
Boils / Skin Abscess
Encyclopedia section of medindia gives general info about Boils / Skin Abscess ...
Hives or Urticaria are allergic skin reaction that appear suddenly in clusters or as single bumps on...
Pemphigus is a rare group of autoimmune diseases that affect the skin and mucous membranes causing b...
Pityriasis Rosea
Pityriasis rosea is a common skin disease that is not contagious. It manifests as oval-shaped, pink ...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...
Ultra-Violet Radiation
Ultraviolet radiations are electromagnetic radiations with wavelengths shorter than the shortest wav...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use