New research has shed light on a key molecule called IQGAP1 that can suppress growth of liver tumors by altering the micro-environment of cancer cells.
The finding offers new insight into cancer metastasis, the ability of a tumour to spread from its primary site to distant organs such as the brain, lung or liver.
Alcoholic Liver Disease
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease.
Advertisement
The discovery paves the way to newer therapies for preventing or treating liver metastases, the major cause of death from cancer.
"Tumour cells are intelligent - they talk to the cells in their surroundings to change the way they behave and make the environment supportive of cancer growth," said senior study author Ningling Kang, biochemist and molecular biologist at Mayo Clinic Cancer Centre, the Journal of Clinical Investigation reports.
"If we can disrupt the communication between the tumour cells and the tumour micro-environment, we can prevent tumour growth or metastasis in the liver," Kang was quoted as saying in a Mayo Clinic statement.
To study the effects of IQGAP1, which controls the shape and movement of cells, Kang and her colleagues implanted tumour cells into the livers of mice genetically engineered to lack the molecule.
The implanted tumour cells still had the molecule, but the cells that made up the tumour microenvironment did not.
When researchers compared the progression of cancer between mutant and normal mice, they found that mice without the molecule developed more liver metastases.
Kang and colleagues showed that IQGAP1 interacts with and suppresses a powerful signalling molecule called TGF-beta receptor that tells normal cells that surround a tumour cell to become tumour-promoting cells.
Source: IANS
Advertisement
"If we can disrupt the communication between the tumour cells and the tumour micro-environment, we can prevent tumour growth or metastasis in the liver," Kang was quoted as saying in a Mayo Clinic statement.
To study the effects of IQGAP1, which controls the shape and movement of cells, Kang and her colleagues implanted tumour cells into the livers of mice genetically engineered to lack the molecule.
The implanted tumour cells still had the molecule, but the cells that made up the tumour microenvironment did not.
When researchers compared the progression of cancer between mutant and normal mice, they found that mice without the molecule developed more liver metastases.
Kang and colleagues showed that IQGAP1 interacts with and suppresses a powerful signalling molecule called TGF-beta receptor that tells normal cells that surround a tumour cell to become tumour-promoting cells.
Source: IANS
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Cancer News
More affected relatives, higher lung cancer risk; participants with affected mothers or siblings faced increased risk.
Colorectal cancer can be lowered by up to 7% by increasing dietary consumption of folate rich foods like spinach, broccoli or taking folate supplements.
The effects and mechanisms of microRNA-451a (miR-451a), which hinders the progression of gemcitabine-resistant biliary tract cancers, are under study.
The blood test pinpointed 13 proteins capable of distinguishing between early and late stages of pancreatic cancer.
A fatty acid present in dairy products, beef, and lamb called trans-vaccenic acid enhances immune cells' capacity to combat cancers.