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Research Highlights Overexpression of Notch1 in Temporal Lobe Epilepsy

by Kathy Jones on May 10, 2014 at 3:46 PM
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 Research Highlights Overexpression of Notch1 in Temporal Lobe Epilepsy

Previous research has shown that a type of signalling called Notch1 signaling can induce astrogliosis in glioma.

However, it remains unknown whether Notch1 signaling is involved in the pathogenesis of epilepsy. A recent study by Xijin Liu and co-workers from Huazhong University of Science and Technology in China observed overexpression of Notch1 in the brain tissue of temporal lobe epilepsy rats.

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After Notch1 regulation, it was relatively effective in reducing seizure frequency and reducing brain discharges, thereby resulting in the ease of seizures to a certain extent. Increased presence of Notch 1 and hairy and enhancer of split-1 was also observed in intractable temporal lobe epilepsy patients. Therefore, Notch signaling may play a role in the pathogenesis of epilepsy in temporal lobe epilepsy and its suppression may provide a new treatment to promote remission in epilepsy. These findings were published in the Neural Regeneration Research (Vol. 9, No. 5, 2014).



Source: Eurekalert
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