About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Research Highlights New Discovery Related to Gum Disease

by Kathy Jones on September 13, 2012 at 9:07 PM
Font : A-A+

 Research Highlights New Discovery Related to Gum Disease

A way to prevent inflammation and bone loss surrounding the teeth has been identified by a University of Louisville scientist. He has achieved this by blocking a natural signaling pathway of the enzyme GSK3b, which plays an important role in directing the immune response.

The discovery of UofL School of Dentistry researcher David Scott, PhD, and his team recently published on-line first in the journal Molecular Medicine. The finding not only has implications in preventing periodontal disease, a chronic inflammatory disease that causes tooth loss, but also may have relevance to other chronic inflammatory diseases. Since GSK3b is involved in multiple inflammatory signaling pathways, it is associated with a number of diseases and also is being tested by scientists for its impact in Alzheimer's disease, Type II diabetes and some forms of cancer, to name a few.

Advertisement

"The traditional approach to dealing with periodontal disease is to prevent plaque from forming at the gum-line or prevent the consequences of periodontal disease progression," Scott said. "Our approach manipulates a natural mechanism within our bodies to prevent inflammation and subsequent degradation when exposed to the bacterium P. gingivalis."

GSK3b is known to facilitate the inflammation that occurs during bacterial infections, so blocking this enzyme from completing its normal function by using the GSK3-specific inhibitor, SB216763 stopped the inflammation process and subsequent bone loss induced by the key periodontal pathogen, P. gingivalis, Scott said.

The next step is for Scott and his team to determine whether SB216763 has any side-effects or whether they need to search for a different inhibitor of GSK3b.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Swollen Gums Tooth Discoloration Dental Check-Up 

Most Popular on Medindia

A-Z Drug Brands in India Blood - Sugar Chart Sinopril (2mg) (Lacidipine) Drug Interaction Checker Noscaphene (Noscapine) Accident and Trauma Care Post-Nasal Drip Loram (2 mg) (Lorazepam) Find a Hospital Selfie Addiction Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE

×

Research Highlights New Discovery Related to Gum Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests