Dysfunction of the regulatory T cells (Tregs), which function to suppress immune responses of other cells, has been associated with development of immune disorders.
Recent studies suggest that Tregs maintain plasticity even after differentiation, and can be influenced to change their regulatory profile. In this issue of the Journal of Clinical Investigation, Yun-Cai Liu and colleagues at the La Jolla Institute for Allergy and Immunology identified the E3 ubiquitin ligase Itch as a regulator of Tregs stability. The authors found that in the absence of Itch, Tregs took on a Th2 phenotype, which promoted the development of severe antigen-induced airway inflammation, skin lesion formation and other inflammatory characteristics in mice. In a companion commentary, WanJun Chen of the National Institutes of Health discusses the implications of this study on our understanding of allergy and asthma development.
Allergy
An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic reactions are pollen, dust mites, mold spores, pet dander, food, insect stings and medicines.
Source: Eurekalert
Allergy Eye Drops
Eye allergies are treated with different types of eye drops such as lubricants, antihistamines, NSAIDs and corticosteroids. Eye drops are used to reduce allergies, eye infection and help healing.
 Allergy - Symptom EvaluationAn allergic reaction may be mild or severe. It usually involves the skin, respiratory system, eyes, digestive system or blood pressure. | Advertisement
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