Recent Study Establishes That High Burden of AFib Corresponds to Lower Cognitive Function

by Vani Pradeep on  November 20, 2014 at 1:38 PM Research News
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A recent study established an association between lower cognitive function (specifically executive and verbal function) and a high burden of atrial fibrillation (AFib). The study results were proposed at the American Heart Association (AHA) Scientific Sessions. Earlier studies had shown a relationship between AFib, cognitive decline and increased risk of dementia. Yet, this very same study, conducted by researchers at the University of Minnesota, reveal for first time the correlation between high AFib burden - the percent of time a person has AFib - and cognition.
Recent Study Establishes That High Burden of AFib Corresponds to Lower Cognitive Function
Recent Study Establishes That High Burden of AFib Corresponds to Lower Cognitive Function

The study, "Higher Burden of Atrial Fibrillation is Independently Associated with Lower Cognitive Function: The Atherosclerosis Risk in Communities (ARIC) Study (Abstract # 12946)", analyzed 325 participants using iRhythm Technologies' ZIOŽ Patch, a non-invasive, leadless, cardiac monitor that can record and store up to two weeks of ECG data. The study found that compared with participants who did not have AFib, participants with AFib burden of 100%, had lower Animal Naming (AN) and Digit Span Backwards (DSB) scores. The ARIC study is funded by the National Institutes of Health.

"Continuous long-term cardiac monitoring is essential to detect AFib, which may occur infrequently and often has no symptoms," said lead author Dr. Lin Yee Chen, M.D., M.S., Assistant Professor, Cardiovascular Division, Department of Medicine, University of Minnesota. "In order to determine AFib burden, and not just the presence or absence of AFib, continuous monitoring and analysis of all of the data is required. We used the ZIO Service, which analyzes the beat-to-beat data in its entirety, which enabled us to identify a sub-population of patients with lower AFib burden who otherwise would not have been detected."

The ZIOŽ Service is the first long-term continuous monitoring service that is supported by extensive clinical data with peer-reviewed publications, and enables diagnosis earlier in the clinical pathway to improve patient outcomes.

"Advances in continuous heart monitoring solutions have enabled a greater clinical understanding of AFib and other arrhythmias compared to standard ambulatory electrocardiographic monitoring," said Judy Lenane, RN, MHA, executive vice president and chief clinical officer of iRhythm Technologies, Inc. "This new data is significant as it shows for the first time that a patient with persistent atrial fibrillation, as detected through long-term continuous ECG monitoring with a device such as the ZIOŽ Patch, is more likely to have lower cognitive function."

iRhythm Technologies, Inc. was also included in two other poster presentations, including the study, "Non-sustained Ventricular Tachycardia (NSVT) is Independently Associated with Lower Cognitive Executive Function: ARIC Study (Poster #12962)" (presented on November 17 morning) and "Incidence and Timing of High-Risk Arrhythmias with Long-Term Continuous Ambulatory Electrocardiographic Monitoring (Poster #16305)," which will be presented on November 18.

Source: Eurekalert

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