Protein Crystallization Method may be Used to Speed Up Drug Development Process

by Rishika Gupta on  March 28, 2018 at 5:19 PM Drug News
RSS Email Print This Page Comment bookmark
Font : A-A+

Protein Crystallization method can be applied to determine the atomic structure of its biologically active substances, finds a new study. The findings of this study are published in the journal of Chemical Science.
 Protein Crystallization Method may be Used to Speed Up Drug Development Process
Protein Crystallization Method may be Used to Speed Up Drug Development Process

This is usually done by performing X-ray analyses of single crystal structures to determine the ingredient's detailed three-dimensional set-up.

Determining crystal structures more quickly and efficiently

A research group headed up by Bernhard Spingler, a professor at the Department of Chemistry of the University of Zurich, has now modified a method that had previously been used exclusively for the crystallization of proteins and successfully applied it to organic salts.

The team was able to determine the crystal structures of several organic salts with significantly less time and effort. "As organic salts make up about 40 percent of all active pharmaceutical ingredients, this new method can greatly speed up the development of drugs," says Spingler.

Simplified screening of organic salts

The generation of solid salts of organic molecules is a key step in developing certain pharmaceutical ingredients. The positively and negatively charged particles that make up organic salts determine their properties, such as their solubility, crystal shape, ability to absorb water, melting point, and stability.

The search for the ideal negatively charged anion to match the salt's positively charged cation has until now been a very resource-intensive process. Thanks to the semi-automatic combination of ion exchange screening and vapor diffusion for crystallization, this is not only done quicker and at lower costs.

"We can now also determine the structures of the salt combinations directly after screening since doing so only requires only very small amounts," adds crystallography expert Spingler.

Trainee achieves breakthrough

The breakthrough in developing the novel method was achieved by Philipp Nievergelt, a trainee who had spent ten months in Bernhard Spingler's lab after graduating from Gymnasium. The successful junior researcher is listed as the first author of the study and is now four semesters into his business chemistry studies at UZH. "The traineeship got me excited about lab work and encouraged me to continue doing research," explains Nievergelt.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Drug Toxicity Signature Drug Toxicity Drugs Banned in India Magical Millets for Your Health The Basics of Baby Food Diet and Nutrition Tips for Athletes Nutrition IQ 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive