About My Health Careers Internship MedBlogs Contact us
Medindia
LOGIN REGISTER
Advertisement

Prenatal Opioid Exposure Increase Pain Response in Neonates

by Ramya Rachamanti on May 16, 2019 at 6:20 PM
Font : A-A+

Prenatal Opioid Exposure Increase Pain Response in Neonates

Babies who got exposed to opioids before birth reacted more strongly to pain and scored higher in a skin conductance test that measures the electrical differences in skin in response to pain as soon as 24 and 48 hours after birth . They may need special care even before they start to experience withdrawal symptoms, according to Penn State research.

Dr. Christiana Oji-Mmuo, assistant professor of pediatrics, said the study suggests that babies who were exposed to opioids in the womb may need special care earlier than previously thought.

Advertisement


"These babies are responding to pain differently than babies who were not exposed, so maybe we should be paying attention to pain management earlier," Oji-Mmuo said. "If we have to do a painful procedure like a heel lance, we may have to provide extra comforting measures, both during the procedure and after if they continue to be stressed."

Oji-Mmuo said that as opioid use continues to be a problem in the U.S., so does the risk of babies being born with neonatal abstinence syndrome (NAS). She said an estimated 55 to 94 percent of babies born to mothers who used opioids during pregnancy will develop NAS.
Advertisement

According to the researchers, opioids block the release of norepinephrine, a chemical released in the body during times of stress. When the baby is born and is no longer exposed to opioids, the baby experiences a spike in norepinephrine and other chemicals and hormones in the body. This can result in such symptoms as irritability, eating poorly, sweating, fever and seizures, among others.

Oji-Mmuo said that while there are guidelines for screening babies at risk for developing NAS, there is a need for better, objective tools to help predict NAS and its severity earlier in newborns.

"To best take care of these babies, it's important that we recognize babies who are going through withdrawal very early," Oji-Mmuo said. "We wanted to see if two different tests -- skin conductance measures and facial reactions to pain -- would correlate and predict withdrawal in newborns, because we really need accurate ways to assess these babies."

The researchers enrolled 37 newborns -- 22 with prenatal opioid exposure and 15 healthy controls -- for the study. To measure the babies' reaction to pain, the newborns were video-recorded while undergoing a heel stick, a standard procedure that most newborn babies undergo to give blood for screening tests.

To measure skin conductance, a noninvasive device with three electrodes was applied to one foot. The device measured electrical conductance in the skin, which can change when norepinephrine boosts sweat production.

After the data was analyzed, the researchers found that the babies exposed prenatally to opioids had higher skin conductance and reacted more strongly to pain during and after the heel-stick procedures. Additionally, Oji-Mmuo said the babies who had been exposed to opioids continued to be stressed after the procedure was over and they were swaddled and tucked in.

Oji-Mmuo said the results -- recently published in the Journal of Maternal-Fetal & Neonatal Medicine -- suggest that babies who are born exposed to opioids handle pain worse than babies who were not exposed.

"Even after the painful procedure was over, they continued to have higher skin conductance," Oji-Mmuo said. "Even when the procedure was done and they'd been swaddled, they continued to have these higher measures compared to the babies who hadn't been exposed to opioids."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Emotional Healing
Psychosis Risk Related to Cat Parasite
Sedentary Behavior Precipitates Night-Time Hot Flashes
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cannabis Drug Abuse Pregnancy and Antenatal Care Drug Detox Thoracic Outlet Syndrome Painkiller Addiction Prescription Drug Abuse 

Recommended Reading
Newborn Opioid Withdrawal Requires a Cascade of Care
Four interrelated components (prevention, prenatal drug treatment, labor & delivery, and aftercare) ...
Cannabis
Cannabis has a long history of medicinal, recreational, and industrial use and comes from a bushy pl...
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or sub...
Drug Detox
Drug detoxification (or drug detox) is a process that helps drug addicts to give up drugs with less ...
Painkiller Addiction
Painkiller addiction is the use of prescription painkillers in a way not meant by the prescribing do...
Pregnancy and Antenatal Care
What is Antenatal care and its importance during pregnancy for mother and baby, with details on the ...
Prescription Drug Abuse
Prescription drug abuse is consuming prescription medications in a way different from that as prescr...
Thoracic Outlet Syndrome
Thoracic outlet syndrome (TOS) is a rare condition that occurs when blood vessels or nerves become c...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use