About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Potential Target For Ulcerative Colitis Drugs

by Pooja Shete on January 15, 2021 at 7:36 PM
Font : A-A+

Potential Target For Ulcerative Colitis Drugs

The researchers have developed a novel, patient derived, model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease.

The study conducted by researchers from Cleveland Clinic's Lerner Research Institute is published in the journal Nature Communications.

Advertisement


The researchers used this model to identify a promising target that could be blocked to slow the disease progression. Ulcerative colitis occurs due to abnormal reactions of the immune system that lead to inflammation and ulcers on the inner lining of the large intestines. The condition is highly heterogeneous both in terms of patients' symptoms and disease pathology.

Current therapy for ulcerative colitis mainly focuses on suppressing the overactive immune response with anti-inflammatory drugs. However, these therapies have limited long-term efficacy in ulcerative colitis patients.
Advertisement

Research has suggested that both the immune system and the ulcerative colitis microenvironment (the surrounding, less diseased cellular components) interact to drive disease development and progression.

As the immune-suppressing drugs have demonstrated limited success in treating ulcerative colitis, the researchers are studying whether targeting elements of the microenvironment—which include components of the intestinal lining (called the epithelium) and stem cell-like cells called stromal cells--may be a better or complementary treatment approach.

Lead author of the study Emina Huang, MD, staff in the Departments of Cancer Biology and Colorectal Surgery said, "Gaining a more comprehensive understanding of the complex interplay between immune and other cell types will be critical to developing new and more effective ulcerative colitis therapies and tailored, patient-specific treatment approaches."

Dr. Huang and her team developed their model using tissue samples from patients with ulcerative colitis who underwent surgery at Cleveland Clinic. They isolated fibroblasts cells that can be reprogrammed to develop into all-purpose, undifferentiated cells called induced pluripotent stem cells.

For the study, the researchers grew the stem cells in the lab into tiny, three-dimensional tissues that mimic actual organs (called organoids). The diseased organoids reflected histological and functional features commonly observed in ulcerative colitis patients including reduced mucus secretions, faulty barrier integrity of the intestinal lining and over expression of select proteins (including one called CXCL8).

The team was able to rapidly identify novel drug targets and candidates. By blocking CXCL8 expression with a small molecule called repertaxin slowed the disease progression.

Dr. Huang said, "We look forward to further exploring repertaxin's potential benefit in other preclinical and eventual clinical studies. We are hopeful that others will also find this model useful in identifying other potential anti-ulcerative colitis drugs."

This approach used to develop the new ulcerative colitis model can also be used to model other complex diseases.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
Drinking This Popular Beverage May Drop Dementia Risk
Worst Mistakes Parents Make When Talking to Kids
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Ulcerative Colitis Drugs Banned in India Autoimmune Disorders Digestive Tract Ulcers Symptom Evaluation Ileostomy Inflammatory Bowel Disease 

Most Popular on Medindia

Blood Donation - Recipients Sinopril (2mg) (Lacidipine) Drug Interaction Checker Calculate Ideal Weight for Infants How to Reduce School Bag Weight - Simple Tips Diaphragmatic Hernia A-Z Drug Brands in India Noscaphene (Noscapine) Iron Intake Calculator Vent Forte (Theophylline)

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use