Medindia LOGIN REGISTER
Medindia
Advertisement

Non-Opioid Patch For Post Surgery Pain

by Pooja Shete on January 15, 2021 at 8:03 PM
Non-Opioid Patch For Post Surgery Pain

Scientists have developed a bio-compatible surgical patch that releases non-opioid painkillers directly to the site of a wound for days and then dissolves. The polymer patch provides a controlled release of a drug that blocks the enzyme cyclooxygenase-2 (COX-2). This enzyme drives pain and inflammation.

The study led by scientists at Duke University is published in the Journal of Controlled Release.

Advertisement


Author of the paper, Matthew Becker, the Hugo L. Blomquist professor chemistry at Duke said, "We were making hernia meshes and different antimicrobial films. We thought you could potentially put pain drugs or anesthetics in the film if you just sew it in as you're stitching the person up, then you wouldn't necessarily have to prescribe any opioids."

Becker had earlier started a study to investigate non-opioid pain management to help fight the opioid epidemic. The polymer is comprised of poly(ester urea) homopolymers and co-polymers. This polymer erodes slowly and its painkiller dose and duration can be controlled by varying the surface area and thicknesses.
Advertisement

Becker said, "Most polymers that are used in medicine swell, and everything comes out at once. The film is about like a piece of paper. If you can get four or five days of pain control out of the patch and not have to take those other pain drugs, not only do you avoid some of the side effects and risks of addiction, you're concentrating therapy where you need it."

Studies in rat showed that the painkiller stayed in tissue closer to the patch site, rather than entering into the circulating plasma.

Becker has stated that the patch will provide three or four days of wound-pain management, which is the critical period for post-surgical pain. The implantable film is useful in cases like endoscopic procedures and instances where the physicians and patients would like to avoid opioid exposure such as Cesarean births and pediatric surgeries. In mice models of neuropathic pain of diabetes, the pain patch was placed against a nerve and provided a four-day nerve block.

Source: Medindia
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Drug News

Prolonging Market Exclusivity of Brand-name Insulin
Examining FDA and patent records, researchers found that insulin manufacturers prolong market exclusivity for brand-name products.
FDA Boosts Orphan Drug Designations for Myelofibrosis Treatments
The rise in FDA ODD awards indicates a collective endeavor to create new myelofibrosis medications devoid of mechanisms inducing anemia.
Anti-Rheumatic Drugs May Help Prevent Thyroid Disease
The most significant decrease in autoimmune thyroid disease risk was observed in rheumatoid arthritis patients receiving immunomodulatory drugs or 'biological DMARDs'.
Apotransferrin's Potential in Early Stroke Therapy Revealed
Human apotransferrin injected to mice models suffering from intracerebral hemorrhage was found to mitigate the serious effects of stroke.
Anti-cancer Drug Navitoclax Help Treat Lower Back Pain
The reduction of these senescent osteoclasts, possibly through the utilization of current medications, could present a novel approach in managing lower back pain.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Non-Opioid Patch For Post Surgery Pain Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests