Parkinson's Patients Benefited With Deep Brain Stimulation Implants

A new study has revealed that deep brain stimulation implants may help patients with Parkinson's disease for a decade post surgery. One decade after receiving implants that stimulate areas of their brains, patients with Parkinson's disease (PD) appeared to sustain improvement in motor function, although part of the initial benefit wore off mainly because of progressive loss of benefit in other functions, according to the study.

Several previous clinical studies have shown deep brain stimulation of the subthalamic nucleus (STN-DBS) for PD to be effective and safe.

"The motor improvement induced by STN stimulation has been reported to be sustained for up to five to eight years after surgery, although part of the initial benefit progressively deteriorates, mainly because of worsening axial signs," write the researchers.

Anna Castrioto, M.D., from the Universita degli Studi di Perugia, Perugia, Italy, and colleagues conducted a study of 18 patients with advanced PD who had received DBS implants for PD between 1996 and 2000.

Motor assessments were conducted before implantation and at one, five and 10 years.

At 10 years, the combination of medication and STN-DBS was associated with significantly better motor, resting and action tremor, bradykinesia (slowed movement) and rigidity scores.

Compared with baseline, reductions were also seen in the scores in the medication and no medication conditions, the dyskinesia (difficulty controlling movement) and motor fluctuation scores and the levadopa-equivalent daily dose.

However, axial signs (such as posture, gait and balance) showed the most progressive decline in stimulation and medication response.

"Our findings further support the long-term response to STN stimulation in patients with advanced PD, showing a prolonged motor improvement up to 10 years," concluded the authors.

The study was published Online by Archives of Neurology, one of the JAMA/Archives journals.

Source-ANI