About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Organ Transplants may Up the Risk of Kidney Disease in Children

by Dr. Enozia Vakil on October 15, 2013 at 12:02 PM
Font : A-A+

 Organ Transplants may Up the Risk of Kidney Disease in Children

A new study has suggested a strong link between organ transplants of solid organs in children, and the risk of advanced kidney disease. Among these children, the highest risk is in those receiving lung or intestinal transplants, followed by heart and then liver transplants. The researchers say their findings reinforce the importance of continued screening of kidney function in pediatric transplant recipients.

"We found that the risk patterns for kidney disease are different among patients who receive solid-organ transplants as children, compared to adult transplant recipients," said pediatric nephrologist Rebecca L. Ruebner, M.D., of The Children's Hospital of Philadelphia. "Because chronic and end-stage kidney disease carry high burdens of mortality and serious illness, it is important to take preventive measures to slow or prevent disease progression."

Advertisement

Ruebner is the first author of a study published online today in Pediatrics. The senior author is Susan L. Furth, M.D., Ph.D., chief of Nephrology at Children's Hospital.

Using data from the Scientific Registry of Transplant Recipients, the study team analyzed records of 16,600 pediatric patients who received solid-organ transplants (liver, heart, lung, intestine, and heart-lung) from 1990 to 2010 across the U.S. This was the first pediatric study to compare the relative incidence of end-stage kidney disease (ESKD) by type of organ transplant. It was also the first analysis to identify the risk of advanced kidney disease among pediatric solid-organ recipients over a 20-year period.
Advertisement

In this two-decade national cohort, the researchers found that ESKD occurred in 3 percent of pediatric solid-organ recipients, with the highest risk of ESKD among those who received lung transplants or intestinal transplants. Patients who received liver transplants as children had the lowest rate of ESKD.

In contrast, adult liver transplant recipients are known to have the highest risk of ESKD and adult lung transplant recipients have lower risks of ESKD. For both children and adults, intestinal transplantation carries higher risks of ESKD.

"Although the overall incidence of end-stage kidney disease was only 3 percent, the broader burden of chronic kidney disease is much higher in this population of pediatric transplant recipients," said Ruebner. "Children with chronic kidney disease experience a steady decline in kidney function, so we recommend that pediatric healthcare providers carefully follow post-transplant patients to detect any early signs of kidney problems, with early referral, if necessary, to a pediatric nephrologist."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First Dose of COVID-19 Vaccines May Improve Mental Health
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tongue Abnormalities Height and Weight-Kids Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis 

Recommended Reading
Government to Set Up Central Coordinating Agency on Organ Transplants
The government is planning to set up a central coordinating agency on organ transplants, according ....
Study Proves Split Liver Transplants for Young Children to be as Safe as Whole Organ Transplantation
When a liver from a donor is split into two separate portions for transplantation, the smaller ......
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Renal Tubular Acidosis
Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of...
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Tongue Abnormalities
Tongue is the only muscle that is attached to only one end. The abnormalities of the tongue include ...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use