Omega-3 fatty acids could stop or slow the growth in the number of triple-negative breast cancer cells more effectively than cells from luminal types of the disease, say researchers.
The omega-3s worked against all types of cancerous cells, but the effect was observed to be stronger in triple-negative cell lines, reducing proliferation by as much as 90 percent.
Advantages of Eating Fish Foods
Researchers worldwide have discovered that eating fish regularly is good for health. Regular consumption of fish may reduce the risk of diseases such as asthma, prostate cancer and eyesight.
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Omega-3 fatty acids are found in oily fish like sardines and salmon, and also in oils derived from plants like hemp and flax.
Previous studies suggest these compounds can negatively affect critical mechanisms in cancer cells, namely those responsible for proliferation and for apoptosis, or programmed cell death.
![Breast Cancer - Prevention and Management with Lifestyle Changes]( "Breast Cancer - Prevention and Management with Lifestyle Changes")
Lifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up avenues beyond breast cancer. Good habits will allow one to fight breast cancer and to live with dignity.
Lead author on the study Thomas J. Pogash, a scientific technician in the Fox Chase Cancer Center lab of Jose Russo, MD, said that the new work underscores the important role common compounds found in food may play in keeping cancer at bay.
"When you compare a western diet to a mediterranean diet, which has more omega-3s, you see less cancer in the mediterranean diet. They eat much more fish," Pogash said.
When a cancer cell digests omega-3s, the fatty acid is broken down into smaller molecules called metabolites.
Russo, Pogash, and their colleagues tested the effect of large omega-3 parent molecules, as well as their smaller metabolic derivatives, on three luminal cell lines and seven lines that included basal-type triple-negative cells.
Omega-3 and its metabolites were observed to inhibit proliferation in all cell lines, but the effect was dramatically more pronounced in the triple-negative cell lines.
In addition, the metabolites of omega-3 reduced the motility, or ability to move, by 20-60 percent in the triple-negative basal cell lines.
Source: ANI
Breast Cancer - Prevention and Management with Lifestyle Changes
Lifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up avenues beyond breast cancer. Good habits will allow one to fight breast cancer and to live with dignity.
Advertisement
Lead author on the study Thomas J. Pogash, a scientific technician in the Fox Chase Cancer Center lab of Jose Russo, MD, said that the new work underscores the important role common compounds found in food may play in keeping cancer at bay.
"When you compare a western diet to a mediterranean diet, which has more omega-3s, you see less cancer in the mediterranean diet. They eat much more fish," Pogash said.
When a cancer cell digests omega-3s, the fatty acid is broken down into smaller molecules called metabolites.
Russo, Pogash, and their colleagues tested the effect of large omega-3 parent molecules, as well as their smaller metabolic derivatives, on three luminal cell lines and seven lines that included basal-type triple-negative cells.
Omega-3 and its metabolites were observed to inhibit proliferation in all cell lines, but the effect was dramatically more pronounced in the triple-negative cell lines.
In addition, the metabolites of omega-3 reduced the motility, or ability to move, by 20-60 percent in the triple-negative basal cell lines.
Source: ANI
Quiz on Breast Cancer
Breast cancer is one of the leading causes of cancer deaths among women. It is often said that a woman who breast-feeds is at a lower risk of developing cancer compared to another who does not .Are these mere old wives tales or is there some truth in it? This quiz on breast cancer has all the details.
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 Quiz on Omega Fatty AcidsBody can't make omega fatty acids but these are essential for good health. So you have to get them from food sources and supplements. Take this quiz and find out why omega fatty acids are important and what foods are good sources of omega fatty acids. | Advertisement
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