About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Non-Invasive Test may Help Predict Premature Birth, Poor Growth in Babies

by Dr. Enozia Vakil on July 12, 2014 at 12:19 PM
Font : A-A+

 Non-Invasive Test may Help Predict Premature Birth, Poor Growth in Babies

A new research has found that a specific molecule detected in pregnant women could predict whether the baby will be born premature or if the fetus will suffer poor growth. Identifying these conditions early in pregnancy could potentially help reduce complications and manage any difficulties, although more work is needed before the findings can be translated to clinical settings.

Researchers from Imperial College London and the University of Crete analyzed the metabolites - small molecules excreted in urine - of 438 pregnant women in the Rhea cohort. They found that elevated urinary levels of the amino acid lysine were associated with spontaneous premature birth. In contrast, increased levels of a N-acetylated glycoprotein - a molecule consisting of a carbohydrate and a protein - tended to be found in women who had to be induced early.

Advertisement

Decreased levels of a third group of molecules: acetate, formate, tyrosine and trimethylamine were associated with poor fetal development. Women with decreased levels of these urine metabolites also showed signs of an increased risk of diabetes, such as higher blood insulin.The Rhea cohort is a large population case-control mother-child study that started in Crete in 2007. Urine samples were collected early in pregnancy at the first ultrasound appointment.

Preterm birth and fetal growth restriction has been shown to increase the chance of developing metabolic and cardiovascular disorders later in life.Hector Keun, lead researcher from the Department of Surgery and Cancer at Imperial College London, says: "While we know that metabolism in the mother changes substantially during pregnancy to help supply the growing fetus with nutrients, we were surprised to see so early in pregnancy a link between metabolites that we could easily detect in a urine sample and low birthweight.
Advertisement

Our findings imply that it could be possible to improve the identification of women at higher risk of delivering smaller babies or premature delivery using non-invasive metabolic profiling technology early in pregnancy."Further research needs to focus on whether changes in these metabolites are induced by pregnancy or indicate an underlying risk factor. It also remains to be seen if these results can be applied to a wider population and more research is needed before any such test could be used in practice.

Hector Keun says: "Future investigation of the factors that produce the molecules associated with these pregnancy outcomes should improve our understanding of the genetic and environmental factors that influence restricted fetal growth and thus help us to reduce the likelihood of these events. We will also go on to test if exposure to these metabolites during pregnancy has a lasting impact on child development after birth."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Varicocele Testicle Pain - Symptom Evaluation 

Most Popular on Medindia

Find a Hospital Loram (2 mg) (Lorazepam) Calculate Ideal Weight for Infants Drug - Food Interactions Drug Side Effects Calculator Diaphragmatic Hernia Daily Calorie Requirements Sinopril (2mg) (Lacidipine) Vent Forte (Theophylline) Iron Intake Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Non-Invasive Test may Help Predict Premature Birth, Poor Growth in Babies Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests