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New Oral Anticoagulant Drugs Prove to be Effective as Warfarin Against Stroke

by Madhumathi Palaniappan on August 28, 2016 at 1:51 PM
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 New Oral Anticoagulant Drugs Prove to be Effective as Warfarin Against Stroke

Stroke or Brain attack occurs mainly due to an inadequate blood supply to an area in the brain. New oral anticoagulant drugs like dabigatran, rivaroxaban and apixaban proves to be effective as warfarin in preventing stroke with lesser bleeding. This was carried as an observational study on 43,000 patients with atrial fibrillation.

The research team from Denmark mainly compared the benefits of stroke treatment with risk of bleeding between non-vitamin K antagonist oral anticoagulants (NOACs) and vitamin K antagonists (warfarin).

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The study was presented by Dr.Laila Staerk, Research fellow at Herlev and Gentofte University Hospital, Denmark at the European Society of Cardiology Congress in 2016.

Dr Staerk said,"Atrial fibrillation is the most common cardiac rhythm disorder and currently affects more than 10 million Europeans"

Atrial fibrillation is found to be linked with a five-fold risk of stroke, which may lead to disability and death, she also added that in the next forty years, the number of patients with atrial fibrillation would triple with number of Europeans diagnosed may rise to 25 -30 million.
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Oral anticoagulants are used by patients with atrial fibrillation for the treatment of stroke. However, warfarin and Non Vitamin K Oral Antagonist (NOAC) may increase the risk of intracranial bleeding.

Even though there has been several treatment options for stroke treatment, Dr Staerk said, "There has been a need to investigate safety and effectiveness of NOACs versus warfarin in a 'real world' population and our Danish registries provide this opportunity."

The study was conducted with 43,299 patients with atrial fibrillation at the Cardiovascular Research Center at Herlev and Gentofte University Hospital in Denmark.

The findings of the study reported that about 42% patients were found to take warfarin, while 29%, 16% and 13% of the patients were found to take dabigatran, apixaban and rivaroxaban respectively. Around 1054 patients were reported with stroke and about 261 cases were reported with intracranial bleeding.

The risk of having stroke in a year ranged from 2 to 2.5 % . However, the number of cases with intracranial bleeding was found to be significantly less in patients who took dabigatran and apixaban (0.3% to 0.4%) compared to warfarin which was 0.6%

Dr Staerk added that eventhough warfarin and NOAC were found to have similar effects in reducing stroke. NOAC drugs were found to be associated with lesser risk of intracranial bleeding in patients with atrial fibrillation.

She concluded that "Registry studies have some limitations such as the observational design, residual confounding, and confounding by drug indication. In the future it would be exciting to see a head-to-head randomised trial performed to compare the different NOAC treatments in patients with atrial fibrillation."



Source: Medindia
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