Medindia
Advertisement

New approach for Treating and Preventing Diabetic Retinopathy

by Dr. Trupti Shirole on May 27, 2015 at 9:20 AM

New approach for Treating and Preventing Diabetic Retinopathy
Diabetic retinopathy is the most common diabetic eye disease that can lead to blindness. It occurs when normal blood vessels of the eye are replaced over time with abnormal, fragile blood vessels that leak fluid or bleed into the eye, damaging the light-sensitive retina and causing blindness. About 40-45% of Americans with diabetes have diabetic retinopathy, according to the US National Eye Institute. US researchers have now found a new way to restore the eyesight in patients with diabetic retinopathy by blocking a second blood vessel growth protein, along with one that is already well-known. This can help in treating and preventing diabetic retinopathy.
Advertisement

Researchers at the Johns Hopkins University and the University of Maryland said, "Laser-sealing eye blood vessels can save central vision, but this often sacrifices peripheral and night vision." Several recently developed drugs, bevacizumab, ranibizumab and aflibercept, can help treat these blood vessels by blocking the action of VEGF, a so-called growth factor released as part of a chain of signals in response to low oxygen levels, which stimulates the growth of new, often abnormal, blood vessels. Lead author Akrit Sodhi, an assistant professor of ophthalmology at the Johns Hopkins University School of Medicine said, "But studies have shown that although these drugs slow progression to proliferative diabetic retinopathy, it does not reliably prevent it."

To find an explanation, researchers tested levels of VEGF in samples of fluid from the eye taken from healthy people, people with diabetes who did not have diabetic retinopathy and people with diabetic retinopathy of varying severity. While levels of VEGF tended to be higher in people with proliferative diabetic retinopathy, some of their fluid had less VEGF than did the healthy participants. But even the low-VEGF fluid from those with proliferative diabetic retinopathy stimulated blood vessel growth in lab-grown cells. Sodhi said, "The results suggested to us that although VEFG clearly plays an important role in blood vessel growth, it's not the only factor."
Advertisement

A series of experiments in laboratory-grown human cells and mice revealed a second culprit, a protein called angiopoietin-like 4. When the researchers blocked the action of both VEGF and angiopoietin-like 4 in fluid from the eyes of patients with proliferative diabetic retinopathy, it markedly reduced blood vessel growth in lab-grown cells. Sodhi said, "If a drug can be found that safely blocks the second protein's action in patients' eyes, it might be combined with the anti-VEGF drugs to prevent many cases of proliferative diabetic retinopathy."

The research team is now investigating whether angiopoietin-like 4 might also play a role in other eye diseases, such as macular degeneration, which destroys the central portion of the retina.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Lower Respiratory Tract Infections Linked to Obstructive Sleep Apnea in Children
Type 2 Diabetes can be Controlled by Unripen Green Jackfruit Flour
Covid Pandemic: How Parents can Help Kids Deal with Back-to-School Anxiety
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Diabetes Mellitus Diabetes - Self-Monitoring of Blood Glucose (SMBG) Diabetes and Exercise Pregnancy and Complications Vision Blindness Facts Type 2 Diabetes Decoding HbA1c Test for Blood Sugar Diabetes - Foot Care 

Recommended Reading
Diabetic Retinopathy
The term 'diabetic retinopathy' refers to changes in the retina which often occur in people with ......
South Asians at Higher Risk of Developing Diabetic Retinopathy
Diabetic retinopathy is the most common eye disease that's caused by complications arising from ......
Insight into Preventing Eye Diseases Such as Diabetic Retinopathy, Macular Degeneration
Neurons in the eyes produce a chemical that is critical for the survival of blood vessels and ......
Two Key Players Produce Destructive Cascade of Diabetic Retinopathy
During diabetes the retina can be bombarded by reactive oxygen species, prompting events that ......
Decoding HbA1c Test for Blood Sugar
The HbA1c assay is the gold-standard measurement of chronic glycemia and measures the amount of gluc...
Diabetes - Foot Care
Valuable information on diabetic foot care, treatment and prevention....
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Pregnancy and Complications
In-depth guide for expecting mothers to overcome health complications related to early or late pregn...
Type 2 Diabetes
Globalization and changing lifestyles has made diabetes very common in developing countries so much ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use