About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Insights into Parkinsonís Treatment

by Colleen Fleiss on February 28, 2018 at 1:31 AM
Font : A-A+

New Insights into Parkinsonís Treatment

Cardiolipin molecule found inside nerve cells ensures that alpha-synuclein protein folds properly. Misfolding of alpha-synuclein protein leads to protein deposits that are the hallmark of Parkinson's disease, a fatal neurodegenerative disorder.

"Identifying the crucial role cardiolipin plays in keeping these proteins functional means cardiolipin has a role in the development of therapies against Parkinson's disease," said Scott Ryan, Professor at the University of Guelph in Ontario, Canada.

Advertisement


"Currently there are no treatments that stop nerve cells from dying," Ryan added.

These deposits are toxic to nerve cells that control voluntary movement. When too many of these deposits accumulate, nerve cells die, the researchers said.
Advertisement

For the study, published in the journal Nature Communications, researchers used stem cells collected from people with the disease. The team studied how nerve cells try to cope with misfolded alpha-synuclein.

"We thought if we can better understand how cells normally fold alpha-synuclein, we may be able to exploit that process to dissolve these aggregates and slow the spread of the disease," Ryan said.

The study revealed that, inside cells, alpha-synuclein binds to mitochondria, where cardiolipin resides. Cells use mitochondria to generate energy and drive metabolism.

Normally, cardiolipin in mitochondria pulls synuclein out of toxic protein deposits and refolds it into a non-toxic shape, the researchers added.

The researchers found that, in people with Parkinson's disease, this process is overwhelmed over time and mitochondria are ultimately destroyed.

"As a result, the cells slowly die. Based on this finding, we now have a better understanding of why nerve cells die in Parkinson's disease and how we might be able to intervene," the researchers noted.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Cochlear Implants may Consequently Drive Hearing Loss
E-cigarettes Use Linked to Erectile Dysfunction
Memory Loss - Can it be Recovered?
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Quiz on Parkinsonís Disease
Parkinson's disease is a disease of the central nervous system. Here's an interesting quiz to find ....
New, Rapid Brain Test for Parkinsonís, Dementia With Lewy Bodies
New and rapid assay test helps detect Parkinson's disease and dementia with Lewy bodies....
Novel Treatment Effective to Treat Symptoms of Parkinsonís Disease
Standard drug treatment for Parkinson's disease may induce motor complications thus reducing the ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use