About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New, Rapid Brain Test for Parkinsonís, Dementia With Lewy Bodies

by Colleen Fleiss on February 12, 2018 at 1:14 AM
Font : A-A+

New, Rapid Brain Test for Parkinsonís, Dementia With Lewy Bodies

Novel test for diagnosis of prion diseases offers the possibility of improving early diagnosis of Parkinson's disease and dementia with Lewy bodies. The group, led by NIH's National Institute of Allergy and Infectious Diseases (NIAID), tested 60 cerebral spinal fluid samples, including 12 from people with Parkinson's disease, 17 from people with dementia with Lewy bodies, and 31 controls, including 16 of whom had Alzheimer's disease. The test correctly excluded all the 31 controls and diagnosed both Parkinson's disease and dementia with Lewy bodies with 93 percent accuracy.

Importantly, test results were available within two days, compared to related assays that require up to 13 days. The group conducted the tests using Real-Time Quaking-Induced Conversion (RT-QuIC), an assay developed and refined over the past decade at NIAID's Rocky Mountain Laboratories. Scientists from the University of California San Diego, University of Verona in Italy, Indiana University School of Medicine, Indianapolis, and the Case Western Reserve University School of Medicine, Cleveland, collaborated on the project. The research findings were published in Acta Neuropathologica Communications.

Advertisement


Multiple neurological disorders, including Parkinson's disease and dementia with Lewy bodies, involve the abnormal clumping of a protein called alpha-synuclein into brain deposits called Lewy bodies. The pathological processes in these diseases resemble prion diseases in mammal brains. Like prion diseases, Parkinson's disease and dementia with Lewy bodies result in progressive deterioration of brain functions and, ultimately, death. Parkinson's disease is about 1,000 times more common than prion diseases, affecting up to 1 million people in the United States, with 60,000 new cases diagnosed each year. Lewy body dementia affects an estimated 1.4 million people in the United States, according to the Lewy Body Dementia Association.

Early and accurate diagnoses of these brain disorders are essential for developing treatments and identifying patients eligible for clinical trials. The diseases typically progress for years before symptoms appear, and once they do, distinguishing one disease from another can be difficult.
Advertisement

The NIAID group continues to adapt the RT-QuIC assay to detect additional types of neurological diseases with greater accuracy using the least invasive patient sample possible--whether that is blood, skin, nasal brushings, or other samples. The group also has trained many international colleagues to use and advance the test.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alzheimers Disease Parkinsons Disease Parkinsons Disease Surgical Treatment Undescended Testicles Brain Varicocele Brain Facts Ataxia Testicle Pain - Symptom Evaluation Language Areas in The Brain 

Recommended Reading
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Test Your Knowledge on Dementia
Dementia is a leading cause of disability in older people. It is a condition where brain cells are ....
Seizure Drug can Help Treat Lewy Body Dementia
Identification of a drug that treats seizure can also treat Lewy body dementia by reducing movement ...
Prion Protein Traced in Skin of CJD Patients
Creutzfeldt-Jakob disease is an incurable and ultimately fatal, transmissible, neurodegenerative ......
Alzheimers Disease
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and mak...
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Testicle Pain - Symptom Evaluation
A sudden, severe pain in the testis may be due to testicular torsion. Testicles inside the scrotum a...
Undescended Testicles
An undescended testicle / testis is one that has not descended into the scrotal sac before birth. It...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use