New immunotherapy to combat pancreatic and ovarian cancers was found out by Stephen T.C. Wong, Ph.D., from Houston Methodist Cancer Center and Samuel Mok, Ph.D., from The University of Texas MD Anderson Cancer Center who published their findings in the journal Clinical Cancer Research.
Known as two of the most lethal cancers, ovarian and pancreatic cancer are often called silent killers since they rarely have early symptoms. As a result, they frequently go undetected until they're too late to effectively treat.
Wong, Mok, and colleagues developed a monoclonal antibody to block the action of a protein secreted by the cells surrounding and supporting tumors in ovarian and pancreatic cancers, called MFAP5. This protein is found at high levels in patients with both these cancers and associated with decreased survival rates.
The MFAP5 protein has been shown to trigger the formation of these surrounding elements that supply and stimulate the tumor, influencing how it grows and spreads. Blocking it prevents new blood vessels and excess tissue from forming within the microenvironment, thereby cutting off the tumor's blood supply and support.
Mok, who is an endowed professor of gynecologic oncology and reproductive medicine at MD Anderson explains, "MFAP5 promotes fibrosis in ovarian and pancreatic cancers, and fibrosis promotes progression, chemoresistance and reduces survival of people with these cancers. By blocking this secretory protein with an antibody, we can treat the tumor by targeting multiple cellular types - fibroblasts and blood vessels -- in the tumor microenvironment."
Now that they have demonstrated the feasibility of using their monoclonal antibody to target MFAP5 as a new cancer treatment regimen, the researchers are in the process of designing and generating a humanized anti-MFAP5 antibody for further development as a therapeutic agent to treat ovarian and pancreatic cancers. Wong said they expect to have it ready by the end of the year for efficacy and toxicity testing, followed by a Phase I clinical trial in the following year.
"The convergence of biological science, computational science, and engineering has allowed us to achieve such translational discovery," Wong said.