About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Discovery may Help Create Less Toxic Anti-HIV Drugs

by VR Sreeraman on October 19, 2009 at 12:22 PM
Font : A-A+

 New Discovery may Help Create Less Toxic Anti-HIV Drugs

Scientists from The University of Texas at Austin have unravelled the atomic structure of a key human enzyme - a finding that would help create less toxic anti-HIV drugs.

"Many anti-HIV drugs are designed to stop the process of DNA replication," said Dr. Whitney Yin, assistant professor of chemistry and biochemistry.

Advertisement

"That turns out to be a great thing to do to help cure virus infections, because it stop the processes of viral replication.

"At the same time, however, when you target such a critical process in viruses, you may also target human enzymes that perform similar functions in normal cells, and this is what causes harmful drug side effects," Yin added.
Advertisement

During the study, Yin and Young-sam Lee unravelled the atomic structure of an enzyme, known as Pol ? (pol gamma), that is responsible for DNA replication in human mitochondria.

When mitochondria are working normally, they produce most of the energy that sustains human cells. When pol gamma comes into contact with certain anti-retroviral drugs, however, it can incorporate the drug into mitochondrial DNA, and thus interfere with the normal replication process.

This interferes with the ability of mitochondria to function. The consequences can range from simple nausea to bone marrow depletion to organ failure.

"Patients who are taking this class of anti-HIV drugs have suffered these drug toxicities for a long time. Dosages and combinations of drugs can be chosen so they don't kill you, but they still can't be used at their most effective concentrations against HIV," said Yin.

"However, in large part because combination therapies have become more successful and patients are living longer, toxicity has become more of an issue than before," Yin added.

The study is published this week in Cell.

Source: ANI
LIN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity 

Recommended Reading
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a ....
Approved Drugs for AIDS/HIV
Encyclopedia section of medindia explains in brief about currently approved drugs for AIDS/HIV...
HIV Drug Development Should Focus on Immune Cells
HIV drug development should target immune cells called macrophages, a new study has suggested....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use