About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Approach to Promote Self-healing After Heart Attack Developed

by Colleen Fleiss on July 10, 2019 at 11:26 AM
Font : A-A+

New Approach to Promote Self-healing After Heart Attack Developed

Annexin A1-based therapy looks like a promising approach to mitigating the effects of acute heart attacks, revealed new study published in the Journal of the American College of Cardiology.

Myocardial infarction (MI) results in the localized death of the muscle cells that are essential for the heart's pumping function. Depending on the extent of the damage, MI may initiate a progressive deterioration of cardiac function that ultimately leads to heart failure. Following an acute infarction, cells of the immune system induce an inflammatory reaction in the heart muscle, which promotes clearance of the damaged tissue. "Many novel post-infarct therapies are designed to inhibit the inflammation," says Professor Oliver Söhnlein of the Institute for Cardiovascular Prevention at LMU. "However, inflammatory reactions everywhere in the body are normally self-limiting. So we set out to develop a therapeutic approach which makes use of the endogenous processes that enable the inflammation to be turned off," he explains.

Advertisement


At the core of their strategy is the protein annexin A1 (AnxA1), which plays an important role in the regulation of the innate immune response - in particular in the switch from the damage-disposal phase of inflammation to the restorative processes that lead to its resolution and healing. In the new study, the authors used two strains of mice. One lacked the ability to synthesize AnxA1, while the other served as the positive control. In mice that were unable to produce AnxA1, the inflammatory reaction induced by MI was more widespread and persistent, and the degree of impairment of cardiac function was greater, than in the control mice. Furthermore, therapeutic administration of AnxA1 following heart damage was found to promote myocardial repair in wild type mice.

The protein causes immune cells called macrophages to secrete the signal protein VEGF-A, which stimulates the formation of new blood vessels. He and his colleagues have observed similar positive effects of AnxA1 on the repair of heart damage in pigs.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
Seasonal Allergy Medications
How to Choose the Best Eczema-Friendly Moisturizer for Children?
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chest Pain Cardiac Catheterization Heart Attack Diet Lifestyle and Heart Disease Coronary Artery Bypass Grafting Stress and the Gender Divide Heart Attack Facts Heart Heart Attack- Lifestyle Risks Healthy Heart 

Most Popular on Medindia

Vent Forte (Theophylline) Iron Intake Calculator Color Blindness Calculator Loram (2 mg) (Lorazepam) A-Z Drug Brands in India Indian Medical Journals Drug Side Effects Calculator Find a Hospital Noscaphene (Noscapine) Sanatogen

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE